Dual-specificity phosphatases 2

Surprising positive effect at the molecular level and a potential biomarker of diseases

W. Wei, Yan Jiao, Arnold Postlethwaite, John Stuart, Y. Wang, D. Sun, Weikuan Gu

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Dual-specificity phosphatases (DUSPs) is an emerging subclass of the protein tyrosine phosphatase gene superfamily, a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Recently, a series of investigations of DUSPs defined their essential roles in cell proliferation, cancer and the immune response. This review will focus on DUSP2, its involvement in different diseases and its potential as a therapeutic target.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalGenes and Immunity
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Dual Specificity Phosphatase 2
Dual-Specificity Phosphatases
Biomarkers
Phosphothreonine
Phosphoserine
Phosphotyrosine
Protein Tyrosine Phosphatases
Phosphoprotein Phosphatases
Cell Proliferation
Genes
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics
  • Genetics(clinical)

Cite this

Dual-specificity phosphatases 2 : Surprising positive effect at the molecular level and a potential biomarker of diseases. / Wei, W.; Jiao, Yan; Postlethwaite, Arnold; Stuart, John; Wang, Y.; Sun, D.; Gu, Weikuan.

In: Genes and Immunity, Vol. 14, No. 1, 01.01.2013, p. 1-6.

Research output: Contribution to journalReview article

@article{d531e3f563fb4480bda0d94c192747e5,
title = "Dual-specificity phosphatases 2: Surprising positive effect at the molecular level and a potential biomarker of diseases",
abstract = "Dual-specificity phosphatases (DUSPs) is an emerging subclass of the protein tyrosine phosphatase gene superfamily, a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Recently, a series of investigations of DUSPs defined their essential roles in cell proliferation, cancer and the immune response. This review will focus on DUSP2, its involvement in different diseases and its potential as a therapeutic target.",
author = "W. Wei and Yan Jiao and Arnold Postlethwaite and John Stuart and Y. Wang and D. Sun and Weikuan Gu",
year = "2013",
month = "1",
day = "1",
doi = "10.1038/gene.2012.54",
language = "English (US)",
volume = "14",
pages = "1--6",
journal = "Genes and Immunity",
issn = "1466-4879",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Dual-specificity phosphatases 2

T2 - Surprising positive effect at the molecular level and a potential biomarker of diseases

AU - Wei, W.

AU - Jiao, Yan

AU - Postlethwaite, Arnold

AU - Stuart, John

AU - Wang, Y.

AU - Sun, D.

AU - Gu, Weikuan

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Dual-specificity phosphatases (DUSPs) is an emerging subclass of the protein tyrosine phosphatase gene superfamily, a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Recently, a series of investigations of DUSPs defined their essential roles in cell proliferation, cancer and the immune response. This review will focus on DUSP2, its involvement in different diseases and its potential as a therapeutic target.

AB - Dual-specificity phosphatases (DUSPs) is an emerging subclass of the protein tyrosine phosphatase gene superfamily, a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Recently, a series of investigations of DUSPs defined their essential roles in cell proliferation, cancer and the immune response. This review will focus on DUSP2, its involvement in different diseases and its potential as a therapeutic target.

UR - http://www.scopus.com/inward/record.url?scp=84872942425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872942425&partnerID=8YFLogxK

U2 - 10.1038/gene.2012.54

DO - 10.1038/gene.2012.54

M3 - Review article

VL - 14

SP - 1

EP - 6

JO - Genes and Immunity

JF - Genes and Immunity

SN - 1466-4879

IS - 1

ER -