Dusts causing pneumoconiosis generate OH and produce hemolysis by acting as fenton catalysts

Thomas P. Kennedy, Ronald Dodson, N. V. Rao, Henry Ky, Christopher Hopkins, Michael Baser, Elizabeth Tolley, John R. Hoidal

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Silicates causing pneumoconiosis function as Fenton catalysts to generate hydroxyl radicals (.OH) when incubated with hydrogen peroxide and a reducing substance. In contrast, silicates which do not cause pneumoconiosis demonstrate no Fenton activity. Catalytic activity is decreased by pretreatment of silicates with the iron chelators deferoxamine or transferrin. Hemolysis from silicates is decreased by interventions which remove superoxide anion or hydrogen peroxide from the medium, or by pretreatment of dusts with iron chelators. Thus, asbestos and nonfibrous silicates may cause pneumoconiosis through a common oxidant mechanism by catalyzing production of toxic .OH radicals in the lung.

Original languageEnglish (US)
Pages (from-to)359-364
Number of pages6
JournalArchives of Biochemistry and Biophysics
Volume269
Issue number1
DOIs
StatePublished - Feb 15 1989

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Pneumoconiosis
Silicates
Hemolysis
Dust
Catalysts
Chelating Agents
Hydrogen Peroxide
Iron
Deferoxamine
Poisons
Asbestos
Transferrin
Oxidants
Superoxides
Hydroxyl Radical
Catalyst activity
Lung

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology

Cite this

Kennedy, T. P., Dodson, R., Rao, N. V., Ky, H., Hopkins, C., Baser, M., ... Hoidal, J. R. (1989). Dusts causing pneumoconiosis generate OH and produce hemolysis by acting as fenton catalysts. Archives of Biochemistry and Biophysics, 269(1), 359-364. https://doi.org/10.1016/0003-9861(89)90118-5

Dusts causing pneumoconiosis generate OH and produce hemolysis by acting as fenton catalysts. / Kennedy, Thomas P.; Dodson, Ronald; Rao, N. V.; Ky, Henry; Hopkins, Christopher; Baser, Michael; Tolley, Elizabeth; Hoidal, John R.

In: Archives of Biochemistry and Biophysics, Vol. 269, No. 1, 15.02.1989, p. 359-364.

Research output: Contribution to journalArticle

Kennedy, Thomas P. ; Dodson, Ronald ; Rao, N. V. ; Ky, Henry ; Hopkins, Christopher ; Baser, Michael ; Tolley, Elizabeth ; Hoidal, John R. / Dusts causing pneumoconiosis generate OH and produce hemolysis by acting as fenton catalysts. In: Archives of Biochemistry and Biophysics. 1989 ; Vol. 269, No. 1. pp. 359-364.
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