DXS28 (C7) maps centromeric to DXS68 (L1-4) and DXS67 (B24) by deletion analysis

Jeffrey Towbin, Jeffrey S. Chamberlain, Darong Wu, De Ann M. Pillers, William K. Seltzer, Edward R.B. McCabe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Complex glycerol kinase deficiency (CGKD) is a contiguous gene syndrome consisting of glycerol kinase deficiency together with Duchenne muscular dystrophy (DMD), congenital adrenal hypoplasia, and/or Ȧland Island eye disease. Deletion mapping of genomic DNA from patients with CGKD was carried out and allowed definitive ordering of loci DXS28 (C7), DXS68 (L1-4), and DXS67 (B24). Most reports have placed DXS68 centromeric to DXS28 and DXS67 on the basis of the initial mapping of the Iowa patient 3, but others have presented evidence consistent with the placement of DXS28 telomeric to DXS68 and DXS67. Through the use of DNA from CGKD patients with a variety of genomic deletions, this controversy is resolved and the order Xcen...DMD-DXS28-DXS68-DXS67...pter is definitively demonstrated.

Original languageEnglish (US)
Pages (from-to)442-444
Number of pages3
JournalGenomics
Volume7
Issue number3
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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Duchenne Muscular Dystrophy
Eye Diseases
DNA
Islands
Hyperglycerolemia
Genes
X-linked adrenal hypoplasia congenita

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Towbin, J., Chamberlain, J. S., Wu, D., Pillers, D. A. M., Seltzer, W. K., & McCabe, E. R. B. (1990). DXS28 (C7) maps centromeric to DXS68 (L1-4) and DXS67 (B24) by deletion analysis. Genomics, 7(3), 442-444. https://doi.org/10.1016/0888-7543(90)90181-S

DXS28 (C7) maps centromeric to DXS68 (L1-4) and DXS67 (B24) by deletion analysis. / Towbin, Jeffrey; Chamberlain, Jeffrey S.; Wu, Darong; Pillers, De Ann M.; Seltzer, William K.; McCabe, Edward R.B.

In: Genomics, Vol. 7, No. 3, 01.01.1990, p. 442-444.

Research output: Contribution to journalArticle

Towbin, J, Chamberlain, JS, Wu, D, Pillers, DAM, Seltzer, WK & McCabe, ERB 1990, 'DXS28 (C7) maps centromeric to DXS68 (L1-4) and DXS67 (B24) by deletion analysis', Genomics, vol. 7, no. 3, pp. 442-444. https://doi.org/10.1016/0888-7543(90)90181-S
Towbin, Jeffrey ; Chamberlain, Jeffrey S. ; Wu, Darong ; Pillers, De Ann M. ; Seltzer, William K. ; McCabe, Edward R.B. / DXS28 (C7) maps centromeric to DXS68 (L1-4) and DXS67 (B24) by deletion analysis. In: Genomics. 1990 ; Vol. 7, No. 3. pp. 442-444.
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