Dynamic correlation of neuronal activity in rat cerebellar cortex modulated by behavior

Detlef Heck, Felix Kümmell, William T. Thach, Ad Aertsen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Sprague-Dawley rats (2-4 months old) were trained to perform a reaching-grasping task while their head was fixated and multielectrode recordings were performed in the ipsilateral cerebellar hemisphere. Multiunit (MU) activity was recorded with 2-3 electrodes in the Purkinje cell layer at various depths (1.5-4.5 mm) from the pial surface while the animal either performed the reaching-grasping task or was at rest. Recording sites were visually aligned along the transverse or the sagittal axis of Crus IIa. Excess correlations of MU spike activity were calculated at 10-ms time resolution using the joint peristimulus time histogram (JPSTH), to reveal the dynamics of cross-correlations corrected for nonstationarities in spike rates. Peak correlation amplitudes and areas were calculated separately for a time period preceding the movement and for a succeeding period during which the movement occurred. Correlations were compared across different paradigms: transversal versus sagittal alignment of recordings sites and behavior versus rest. No significant differences were found between transversally and sagittally aligned recording sites. Significant differences in peak correlation amplitude and/or peak area, however, were found both between premovement and movement time, as well as between both these time periods and periods while the animal was at rest.

Original languageEnglish (US)
Pages (from-to)156-163
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume978
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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Cerebellar Cortex
Rats
Animals
Cells
Electrodes
Purkinje Cells
Sprague Dawley Rats
Joints
Head
Rat
Cortex

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Dynamic correlation of neuronal activity in rat cerebellar cortex modulated by behavior. / Heck, Detlef; Kümmell, Felix; Thach, William T.; Aertsen, Ad.

In: Annals of the New York Academy of Sciences, Vol. 978, 01.01.2002, p. 156-163.

Research output: Contribution to journalArticle

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