Dysembryoplastic neuroepithelial tumors and cognitive outcome

Cure at a price?

Ibrahim Qaddoumi, David W. Ellison, E. Brannon Morris, Alberto Broniscer, Frederick Boop, Thomas Merchant, Shawna L. Palmer, Amar Gajjar

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Dysembryoplastic neuroepithelial tumors (DNETs) are benign glioneuronal tumors that occur in children. These tumors are characterized by seizures, lack of neurologic deficits, and a seemingly benign course after resection. Methods: A retrospective review was conducted of data relating to 11 children diagnosed with DNETs between January 1988 and December 2007 at St. Jude Children's Research Hospital. This report documented the clinical features, neurocognitive function, and treatment outcomes in this institutional series. Results: The patient cohort included 8 boys and 3 girls (median age at diagnosis, 10 years); all patients presented with seizures: 4 complex partial, 3 generalized tonic-clonic, 2 absence, 1 partial simple, and 1 not classified. Of the 11 patients, 1 died of cardiac fibrosis, and tumors recurred or progressed in 4 (36%) patients. Seizure control was achieved in all patients but 1. Of the 9 patients who completed neuropsychologic testing, only 3 (33%) functioned at or above the expected level of same-age peers. Conclusions: The high recurrence and progression rates of DNETs and the high rate of abnormal neurocognitive test results noted in the current study highlight the need for regular follow-up and appropriate academic counseling of children with these tumors. Cancer 2010. © 2010 American Cancer Society Data were reviewed regarding dysembryoplastic neuroepithelial tumors. The recurrence and progression rates of dysembryoplastic neuroepithelial tumors and the high rate of abnormal neurocognitive test results noted in this study highlight the need for regular follow-up and appropriate academic counseling of children with these tumors.

Original languageEnglish (US)
Pages (from-to)5461-5469
Number of pages9
JournalCancer
Volume116
Issue number23
DOIs
StatePublished - Dec 1 2010

Fingerprint

Neuroepithelial Neoplasms
Seizures
Neoplasms
Counseling
Recurrence
Heart Neoplasms
Neurologic Manifestations
Fibrosis
Research

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Qaddoumi, I., Ellison, D. W., Morris, E. B., Broniscer, A., Boop, F., Merchant, T., ... Gajjar, A. (2010). Dysembryoplastic neuroepithelial tumors and cognitive outcome: Cure at a price? Cancer, 116(23), 5461-5469. https://doi.org/10.1002/cncr.25528

Dysembryoplastic neuroepithelial tumors and cognitive outcome : Cure at a price? / Qaddoumi, Ibrahim; Ellison, David W.; Morris, E. Brannon; Broniscer, Alberto; Boop, Frederick; Merchant, Thomas; Palmer, Shawna L.; Gajjar, Amar.

In: Cancer, Vol. 116, No. 23, 01.12.2010, p. 5461-5469.

Research output: Contribution to journalArticle

Qaddoumi, I, Ellison, DW, Morris, EB, Broniscer, A, Boop, F, Merchant, T, Palmer, SL & Gajjar, A 2010, 'Dysembryoplastic neuroepithelial tumors and cognitive outcome: Cure at a price?', Cancer, vol. 116, no. 23, pp. 5461-5469. https://doi.org/10.1002/cncr.25528
Qaddoumi I, Ellison DW, Morris EB, Broniscer A, Boop F, Merchant T et al. Dysembryoplastic neuroepithelial tumors and cognitive outcome: Cure at a price? Cancer. 2010 Dec 1;116(23):5461-5469. https://doi.org/10.1002/cncr.25528
Qaddoumi, Ibrahim ; Ellison, David W. ; Morris, E. Brannon ; Broniscer, Alberto ; Boop, Frederick ; Merchant, Thomas ; Palmer, Shawna L. ; Gajjar, Amar. / Dysembryoplastic neuroepithelial tumors and cognitive outcome : Cure at a price?. In: Cancer. 2010 ; Vol. 116, No. 23. pp. 5461-5469.
@article{8d7221e79f984db2b4b6415e683b9709,
title = "Dysembryoplastic neuroepithelial tumors and cognitive outcome: Cure at a price?",
abstract = "Background: Dysembryoplastic neuroepithelial tumors (DNETs) are benign glioneuronal tumors that occur in children. These tumors are characterized by seizures, lack of neurologic deficits, and a seemingly benign course after resection. Methods: A retrospective review was conducted of data relating to 11 children diagnosed with DNETs between January 1988 and December 2007 at St. Jude Children's Research Hospital. This report documented the clinical features, neurocognitive function, and treatment outcomes in this institutional series. Results: The patient cohort included 8 boys and 3 girls (median age at diagnosis, 10 years); all patients presented with seizures: 4 complex partial, 3 generalized tonic-clonic, 2 absence, 1 partial simple, and 1 not classified. Of the 11 patients, 1 died of cardiac fibrosis, and tumors recurred or progressed in 4 (36{\%}) patients. Seizure control was achieved in all patients but 1. Of the 9 patients who completed neuropsychologic testing, only 3 (33{\%}) functioned at or above the expected level of same-age peers. Conclusions: The high recurrence and progression rates of DNETs and the high rate of abnormal neurocognitive test results noted in the current study highlight the need for regular follow-up and appropriate academic counseling of children with these tumors. Cancer 2010. {\circledC} 2010 American Cancer Society Data were reviewed regarding dysembryoplastic neuroepithelial tumors. The recurrence and progression rates of dysembryoplastic neuroepithelial tumors and the high rate of abnormal neurocognitive test results noted in this study highlight the need for regular follow-up and appropriate academic counseling of children with these tumors.",
author = "Ibrahim Qaddoumi and Ellison, {David W.} and Morris, {E. Brannon} and Alberto Broniscer and Frederick Boop and Thomas Merchant and Palmer, {Shawna L.} and Amar Gajjar",
year = "2010",
month = "12",
day = "1",
doi = "10.1002/cncr.25528",
language = "English (US)",
volume = "116",
pages = "5461--5469",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "23",

}

TY - JOUR

T1 - Dysembryoplastic neuroepithelial tumors and cognitive outcome

T2 - Cure at a price?

AU - Qaddoumi, Ibrahim

AU - Ellison, David W.

AU - Morris, E. Brannon

AU - Broniscer, Alberto

AU - Boop, Frederick

AU - Merchant, Thomas

AU - Palmer, Shawna L.

AU - Gajjar, Amar

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Background: Dysembryoplastic neuroepithelial tumors (DNETs) are benign glioneuronal tumors that occur in children. These tumors are characterized by seizures, lack of neurologic deficits, and a seemingly benign course after resection. Methods: A retrospective review was conducted of data relating to 11 children diagnosed with DNETs between January 1988 and December 2007 at St. Jude Children's Research Hospital. This report documented the clinical features, neurocognitive function, and treatment outcomes in this institutional series. Results: The patient cohort included 8 boys and 3 girls (median age at diagnosis, 10 years); all patients presented with seizures: 4 complex partial, 3 generalized tonic-clonic, 2 absence, 1 partial simple, and 1 not classified. Of the 11 patients, 1 died of cardiac fibrosis, and tumors recurred or progressed in 4 (36%) patients. Seizure control was achieved in all patients but 1. Of the 9 patients who completed neuropsychologic testing, only 3 (33%) functioned at or above the expected level of same-age peers. Conclusions: The high recurrence and progression rates of DNETs and the high rate of abnormal neurocognitive test results noted in the current study highlight the need for regular follow-up and appropriate academic counseling of children with these tumors. Cancer 2010. © 2010 American Cancer Society Data were reviewed regarding dysembryoplastic neuroepithelial tumors. The recurrence and progression rates of dysembryoplastic neuroepithelial tumors and the high rate of abnormal neurocognitive test results noted in this study highlight the need for regular follow-up and appropriate academic counseling of children with these tumors.

AB - Background: Dysembryoplastic neuroepithelial tumors (DNETs) are benign glioneuronal tumors that occur in children. These tumors are characterized by seizures, lack of neurologic deficits, and a seemingly benign course after resection. Methods: A retrospective review was conducted of data relating to 11 children diagnosed with DNETs between January 1988 and December 2007 at St. Jude Children's Research Hospital. This report documented the clinical features, neurocognitive function, and treatment outcomes in this institutional series. Results: The patient cohort included 8 boys and 3 girls (median age at diagnosis, 10 years); all patients presented with seizures: 4 complex partial, 3 generalized tonic-clonic, 2 absence, 1 partial simple, and 1 not classified. Of the 11 patients, 1 died of cardiac fibrosis, and tumors recurred or progressed in 4 (36%) patients. Seizure control was achieved in all patients but 1. Of the 9 patients who completed neuropsychologic testing, only 3 (33%) functioned at or above the expected level of same-age peers. Conclusions: The high recurrence and progression rates of DNETs and the high rate of abnormal neurocognitive test results noted in the current study highlight the need for regular follow-up and appropriate academic counseling of children with these tumors. Cancer 2010. © 2010 American Cancer Society Data were reviewed regarding dysembryoplastic neuroepithelial tumors. The recurrence and progression rates of dysembryoplastic neuroepithelial tumors and the high rate of abnormal neurocognitive test results noted in this study highlight the need for regular follow-up and appropriate academic counseling of children with these tumors.

UR - http://www.scopus.com/inward/record.url?scp=78649590980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649590980&partnerID=8YFLogxK

U2 - 10.1002/cncr.25528

DO - 10.1002/cncr.25528

M3 - Article

VL - 116

SP - 5461

EP - 5469

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 23

ER -