Dyslexia-specific brain activation profile becomes normal following successful remedial training

P. G. Simos, J. M. Fletcher, E. Bergman, J. I. Breier, B. R. Foorman, E. M. Castillo, R. N. Davis, M. Fitzgerald, Andrew Papanicolaou

Research output: Contribution to journalArticle

306 Citations (Scopus)

Abstract

Objectives: To examine changes in the spatiotemporal brain activation profiles associated with successful completion of an intensive intervention program in individual dyslexic children. Methods: The authors obtained magnetic source imaging scans during a pseudoword reading task from eight children (7 to 17 years old) before and after 80 hours of intensive remedial instruction. All children were initially diagnosed with dyslexia, marked by severe difficulties in word recognition and phonologic processing. Eight children who never experienced reading problems were also tested on two occasions separated by a 2-month interval. Results: Before intervention, all children with dyslexia showed distinctly aberrant activation profiles featuring little or no activation of the posterior portion of the superior temporal gyrus (STGp), an area normally involved in phonologic processing, and increased activation of the corresponding right hemisphere area. After intervention that produced significant improvement in reading skills, activity in the left STGp increased by several orders of magnitude in every participant. No systematic changes were obtained in the activation profiles of the children without dyslexia as a function of time. Conclusions: These findings suggest that the deficit in functional brain organization underlying dyslexia can be reversed after sufficiently intense intervention lasting as little as 2 months, and are consistent with current proposals that reading difficulties in many children represent a variation of normal development that can be altered by intensive intervention.

Original languageEnglish (US)
Pages (from-to)1203-1213
Number of pages11
JournalNeurology
Volume58
Issue number8
DOIs
StatePublished - Apr 23 2002

Fingerprint

Dyslexia
Brain
Reading

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Simos, P. G., Fletcher, J. M., Bergman, E., Breier, J. I., Foorman, B. R., Castillo, E. M., ... Papanicolaou, A. (2002). Dyslexia-specific brain activation profile becomes normal following successful remedial training. Neurology, 58(8), 1203-1213. https://doi.org/10.1212/WNL.58.8.1203

Dyslexia-specific brain activation profile becomes normal following successful remedial training. / Simos, P. G.; Fletcher, J. M.; Bergman, E.; Breier, J. I.; Foorman, B. R.; Castillo, E. M.; Davis, R. N.; Fitzgerald, M.; Papanicolaou, Andrew.

In: Neurology, Vol. 58, No. 8, 23.04.2002, p. 1203-1213.

Research output: Contribution to journalArticle

Simos, PG, Fletcher, JM, Bergman, E, Breier, JI, Foorman, BR, Castillo, EM, Davis, RN, Fitzgerald, M & Papanicolaou, A 2002, 'Dyslexia-specific brain activation profile becomes normal following successful remedial training', Neurology, vol. 58, no. 8, pp. 1203-1213. https://doi.org/10.1212/WNL.58.8.1203
Simos PG, Fletcher JM, Bergman E, Breier JI, Foorman BR, Castillo EM et al. Dyslexia-specific brain activation profile becomes normal following successful remedial training. Neurology. 2002 Apr 23;58(8):1203-1213. https://doi.org/10.1212/WNL.58.8.1203
Simos, P. G. ; Fletcher, J. M. ; Bergman, E. ; Breier, J. I. ; Foorman, B. R. ; Castillo, E. M. ; Davis, R. N. ; Fitzgerald, M. ; Papanicolaou, Andrew. / Dyslexia-specific brain activation profile becomes normal following successful remedial training. In: Neurology. 2002 ; Vol. 58, No. 8. pp. 1203-1213.
@article{1a3b77f8fe23418587f77b2a3af34a32,
title = "Dyslexia-specific brain activation profile becomes normal following successful remedial training",
abstract = "Objectives: To examine changes in the spatiotemporal brain activation profiles associated with successful completion of an intensive intervention program in individual dyslexic children. Methods: The authors obtained magnetic source imaging scans during a pseudoword reading task from eight children (7 to 17 years old) before and after 80 hours of intensive remedial instruction. All children were initially diagnosed with dyslexia, marked by severe difficulties in word recognition and phonologic processing. Eight children who never experienced reading problems were also tested on two occasions separated by a 2-month interval. Results: Before intervention, all children with dyslexia showed distinctly aberrant activation profiles featuring little or no activation of the posterior portion of the superior temporal gyrus (STGp), an area normally involved in phonologic processing, and increased activation of the corresponding right hemisphere area. After intervention that produced significant improvement in reading skills, activity in the left STGp increased by several orders of magnitude in every participant. No systematic changes were obtained in the activation profiles of the children without dyslexia as a function of time. Conclusions: These findings suggest that the deficit in functional brain organization underlying dyslexia can be reversed after sufficiently intense intervention lasting as little as 2 months, and are consistent with current proposals that reading difficulties in many children represent a variation of normal development that can be altered by intensive intervention.",
author = "Simos, {P. G.} and Fletcher, {J. M.} and E. Bergman and Breier, {J. I.} and Foorman, {B. R.} and Castillo, {E. M.} and Davis, {R. N.} and M. Fitzgerald and Andrew Papanicolaou",
year = "2002",
month = "4",
day = "23",
doi = "10.1212/WNL.58.8.1203",
language = "English (US)",
volume = "58",
pages = "1203--1213",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Dyslexia-specific brain activation profile becomes normal following successful remedial training

AU - Simos, P. G.

AU - Fletcher, J. M.

AU - Bergman, E.

AU - Breier, J. I.

AU - Foorman, B. R.

AU - Castillo, E. M.

AU - Davis, R. N.

AU - Fitzgerald, M.

AU - Papanicolaou, Andrew

PY - 2002/4/23

Y1 - 2002/4/23

N2 - Objectives: To examine changes in the spatiotemporal brain activation profiles associated with successful completion of an intensive intervention program in individual dyslexic children. Methods: The authors obtained magnetic source imaging scans during a pseudoword reading task from eight children (7 to 17 years old) before and after 80 hours of intensive remedial instruction. All children were initially diagnosed with dyslexia, marked by severe difficulties in word recognition and phonologic processing. Eight children who never experienced reading problems were also tested on two occasions separated by a 2-month interval. Results: Before intervention, all children with dyslexia showed distinctly aberrant activation profiles featuring little or no activation of the posterior portion of the superior temporal gyrus (STGp), an area normally involved in phonologic processing, and increased activation of the corresponding right hemisphere area. After intervention that produced significant improvement in reading skills, activity in the left STGp increased by several orders of magnitude in every participant. No systematic changes were obtained in the activation profiles of the children without dyslexia as a function of time. Conclusions: These findings suggest that the deficit in functional brain organization underlying dyslexia can be reversed after sufficiently intense intervention lasting as little as 2 months, and are consistent with current proposals that reading difficulties in many children represent a variation of normal development that can be altered by intensive intervention.

AB - Objectives: To examine changes in the spatiotemporal brain activation profiles associated with successful completion of an intensive intervention program in individual dyslexic children. Methods: The authors obtained magnetic source imaging scans during a pseudoword reading task from eight children (7 to 17 years old) before and after 80 hours of intensive remedial instruction. All children were initially diagnosed with dyslexia, marked by severe difficulties in word recognition and phonologic processing. Eight children who never experienced reading problems were also tested on two occasions separated by a 2-month interval. Results: Before intervention, all children with dyslexia showed distinctly aberrant activation profiles featuring little or no activation of the posterior portion of the superior temporal gyrus (STGp), an area normally involved in phonologic processing, and increased activation of the corresponding right hemisphere area. After intervention that produced significant improvement in reading skills, activity in the left STGp increased by several orders of magnitude in every participant. No systematic changes were obtained in the activation profiles of the children without dyslexia as a function of time. Conclusions: These findings suggest that the deficit in functional brain organization underlying dyslexia can be reversed after sufficiently intense intervention lasting as little as 2 months, and are consistent with current proposals that reading difficulties in many children represent a variation of normal development that can be altered by intensive intervention.

UR - http://www.scopus.com/inward/record.url?scp=0037161287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037161287&partnerID=8YFLogxK

U2 - 10.1212/WNL.58.8.1203

DO - 10.1212/WNL.58.8.1203

M3 - Article

VL - 58

SP - 1203

EP - 1213

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 8

ER -