E-rosette formation, total T-cells, and lymphocyte transformation in infants receiving intravenous safflower oil emulsion

Richard Helms, H. G. Herrod, G. J. Burckart, Michael Christensen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

There has been much concern about impaired immune function in children receiving infused lipid emulsions. Immunologic studies were carried out on 15 infants maintained on parenteral nutrition with intravenous safflower oil emulsion as part of the infusate. Significant increases in percentage rosette formation, total circulating T-cells, and mitogenesis to phytohemagglutinin and pokeweed mitogen were demonstrated after only 1 wk of lipid infusion. Additional parenteral nutrition did not further increase any immunologic parameter. These results suggest that infused safflower oil emulsion does not adversely alter cellular immune function.

Original languageEnglish (US)
Pages (from-to)541-545
Number of pages5
JournalJournal of Parenteral and Enteral Nutrition
Volume7
Issue number6
DOIs
StatePublished - Jan 1 1983

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Safflower Oil
Rosette Formation
Lymphocyte Activation
Emulsions
Parenteral Nutrition
T-Lymphocytes
Lipids
Pokeweed Mitogens
Phytohemagglutinins

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

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AU - Herrod, H. G.

AU - Burckart, G. J.

AU - Christensen, Michael

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AB - There has been much concern about impaired immune function in children receiving infused lipid emulsions. Immunologic studies were carried out on 15 infants maintained on parenteral nutrition with intravenous safflower oil emulsion as part of the infusate. Significant increases in percentage rosette formation, total circulating T-cells, and mitogenesis to phytohemagglutinin and pokeweed mitogen were demonstrated after only 1 wk of lipid infusion. Additional parenteral nutrition did not further increase any immunologic parameter. These results suggest that infused safflower oil emulsion does not adversely alter cellular immune function.

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