Early abnormalities of left ventricular function in essential hypertension induced by exercise.

E. J. Marcó, Alejandro Dopico, F. Otero, A. J. Ramírez, R. A. Sánchez

Research output: Contribution to journalArticle

Abstract

In order to assess their ventricular function at rest and during exercise, 42 essential hypertensives (164 +/- 2/98.7 +/- 2 mmHg) and 12 normotensives (131.7 +/- 4/81.2 +/- 1 mmHg) were studied. Ejection fraction (EF), peak filling rate (PFR) and peak ejection rate (PER) were measured by means of gated radionuclide ventriculography. At rest, no differences in EF, PFR and PER between hypertensives and normotensives were found. During exercise, hypertensives showed lower PFR (5.3 +/- 0.2 EDV/s) and EF (67.7 +/- 1%) than normotensives (PFR 7 +/- 0.5 EDV/s, p < 0.005 and EF 79.4 +/- 2%, p < 0.001). Likewise, hypertensive showed a lower increase from rest to exercise in PFR and in EF than normotensives p < 0.001. In addition, hypertensives showed a great individual variability in EF response to exercise, where 23 patients increased EF more than 5% and 19 patients failed to increase it during stress. Moreover, the last group of patients had higher systolic blood pressure (SBP) both at rest and during exercise than patients who increased EF, p < 0.01. In addition, there was a significantly negative correlation between resting SBP and the variation of Ef (r = 0.47 y: 163.1-0.79X, p < 0.01). Left ventricular mass (LVM) was similar in the two groups of hypertensives. On the other hand, there were no differences in any of the variables analyzed between the hypertensives with LV hypertrophy and those with normal LVM. These findings suggest that abnormalities in both systolic and diastolic LV during exercise may be found in hypertensive patients even before myocardial hypertrophy can be detected.

Original languageEnglish (US)
Pages (from-to)311-319
Number of pages9
JournalMedicina
Volume52
Issue number4
StatePublished - Dec 1 1992
Externally publishedYes

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Left Ventricular Function
Exercise
Blood Pressure
Hypertrophy
Gated Blood-Pool Imaging
Ventricular Function
Essential Hypertension
Hypertension

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Marcó, E. J., Dopico, A., Otero, F., Ramírez, A. J., & Sánchez, R. A. (1992). Early abnormalities of left ventricular function in essential hypertension induced by exercise. Medicina, 52(4), 311-319.

Early abnormalities of left ventricular function in essential hypertension induced by exercise. / Marcó, E. J.; Dopico, Alejandro; Otero, F.; Ramírez, A. J.; Sánchez, R. A.

In: Medicina, Vol. 52, No. 4, 01.12.1992, p. 311-319.

Research output: Contribution to journalArticle

Marcó, EJ, Dopico, A, Otero, F, Ramírez, AJ & Sánchez, RA 1992, 'Early abnormalities of left ventricular function in essential hypertension induced by exercise.', Medicina, vol. 52, no. 4, pp. 311-319.
Marcó, E. J. ; Dopico, Alejandro ; Otero, F. ; Ramírez, A. J. ; Sánchez, R. A. / Early abnormalities of left ventricular function in essential hypertension induced by exercise. In: Medicina. 1992 ; Vol. 52, No. 4. pp. 311-319.
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abstract = "In order to assess their ventricular function at rest and during exercise, 42 essential hypertensives (164 +/- 2/98.7 +/- 2 mmHg) and 12 normotensives (131.7 +/- 4/81.2 +/- 1 mmHg) were studied. Ejection fraction (EF), peak filling rate (PFR) and peak ejection rate (PER) were measured by means of gated radionuclide ventriculography. At rest, no differences in EF, PFR and PER between hypertensives and normotensives were found. During exercise, hypertensives showed lower PFR (5.3 +/- 0.2 EDV/s) and EF (67.7 +/- 1{\%}) than normotensives (PFR 7 +/- 0.5 EDV/s, p < 0.005 and EF 79.4 +/- 2{\%}, p < 0.001). Likewise, hypertensive showed a lower increase from rest to exercise in PFR and in EF than normotensives p < 0.001. In addition, hypertensives showed a great individual variability in EF response to exercise, where 23 patients increased EF more than 5{\%} and 19 patients failed to increase it during stress. Moreover, the last group of patients had higher systolic blood pressure (SBP) both at rest and during exercise than patients who increased EF, p < 0.01. In addition, there was a significantly negative correlation between resting SBP and the variation of Ef (r = 0.47 y: 163.1-0.79X, p < 0.01). Left ventricular mass (LVM) was similar in the two groups of hypertensives. On the other hand, there were no differences in any of the variables analyzed between the hypertensives with LV hypertrophy and those with normal LVM. These findings suggest that abnormalities in both systolic and diastolic LV during exercise may be found in hypertensive patients even before myocardial hypertrophy can be detected.",
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