Early and delayed protection by capsaicin against reperfusion injury in rat hearts

Fuwen Zhou, Yuan Jian Li, Han Wu Deng

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

AIM: To study early or delayed cardioprotection afforded by pretreatment with capsaicin. METHODS: The isolated rat heart was perfused in a Langendorff model. Heart rate, coronary flow, left ventricular pressure, and its first derivative (±dp/dt(max)) were recorded, and the calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and the release of creatine kinase (CK) were measured. RESULTS: Capsaicin (50 mg · kg-1, sc) improved the recovery of cardiac function and decreased the release of CK. CK was (2.12 ± 0.40) and (0.26 ± 0.04) u · min-1 · g-1 (wet wt) for ischemia- reperfusion (I/R) and capsaicin + I/R, respectively (P < 0.05). Capsaicin treatment caused an increase in the concentration of CGRP-LI in plasma. CGRP- LI was (135 ± 12) and (304 ± 45) ng · L-1 for vehicle + I/R and capsaicin + I/R, respectively (P < 0.05). After pretreatment with capsaicin to deplete the sensory nerve transmitter content, the cardioprotection and the increased level of CGRP by capsaicin were abolished. A delayed protection was shown in the hearts obtained from the rats pretreated with capsaicin 24 h or 48 h before the experiments. CONCLUSION: Pretreatment with capsaicin induces the early and delayed cardioprotection, which may be related to stimulation of CGRP release in the rat.

Original languageEnglish (US)
Pages (from-to)912-916
Number of pages5
JournalActa Pharmacologica Sinica
Volume20
Issue number10
StatePublished - Nov 29 1999

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Capsaicin
Reperfusion Injury
Reperfusion
Ischemia
Creatine Kinase
Calcitonin Gene-Related Peptide
Recovery of Function
Ventricular Pressure
Heart Rate

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Early and delayed protection by capsaicin against reperfusion injury in rat hearts. / Zhou, Fuwen; Li, Yuan Jian; Deng, Han Wu.

In: Acta Pharmacologica Sinica, Vol. 20, No. 10, 29.11.1999, p. 912-916.

Research output: Contribution to journalArticle

Zhou, Fuwen ; Li, Yuan Jian ; Deng, Han Wu. / Early and delayed protection by capsaicin against reperfusion injury in rat hearts. In: Acta Pharmacologica Sinica. 1999 ; Vol. 20, No. 10. pp. 912-916.
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