Early diagnosis of subependymal giant cell astocytoma in patients with tuberous sclerosis

Orlando A. Torres, E. S. Roach, Mauricio R. Delgado, Steven P. Sparagana, Eugene Sheffield, Dale Swift, Derek Bruce

Research output: Contribution to journalArticle

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Abstract

We present 19 patients with tuberous sclerosis complex and subependymal giant cell astrocytoma. The mean age at the time of tumor diagnosis was 9.4 years (range, 1.5 to 21 years). Computed cranial tomography (CT) or cranial magnetic resonance imaging (MRI) identified the lesion which was resected in all cases. Seven patients had hydrocephalus and there was an interval increase in the tumor size or a large tumor without hydrocephalus in 12 patients. Surgical criteria included: (1) presence of hydrocephalus; (2) interval increase in tumor size; (3) new focal neurologic deficit attributable to the tumor, and/or (4) symptoms of increased intracranial pressure. Eight patients were identified through a surveillance program involving annual computed cranial tomography. All of these eight patients had their tumor removed prior to the development of symptoms, none had neurologic deficits which persisted after surgery, and none has so far developed recurrent subependymal giant cell astrocytoma. In contrast, of the 11 patients from the non-surveillance group 7 were symptomatic at tumor diagnosis, 1 had a complicated postoperative course, 2 developed recurrent giant cell astrocytoma, and 1 had an extensive lesion that could not be completely excised. Periodic cranial imaging may help to identify subependymal giant cell astrocytomas in tuberous sclerosis patients before they become symptomatic. Earlier diagnosis and treatment could reduce surgical morbidity and the risk of tumor recurrence.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalJournal of Child Neurology
Volume13
Issue number4
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

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Tuberous Sclerosis
Giant Cells
Early Diagnosis
Astrocytoma
Neoplasms
Hydrocephalus
Neurologic Manifestations
Tomography
Intracranial Pressure
Magnetic Resonance Imaging
Morbidity
Recurrence

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Early diagnosis of subependymal giant cell astocytoma in patients with tuberous sclerosis. / Torres, Orlando A.; Roach, E. S.; Delgado, Mauricio R.; Sparagana, Steven P.; Sheffield, Eugene; Swift, Dale; Bruce, Derek.

In: Journal of Child Neurology, Vol. 13, No. 4, 01.01.1998, p. 173-177.

Research output: Contribution to journalArticle

Torres, Orlando A. ; Roach, E. S. ; Delgado, Mauricio R. ; Sparagana, Steven P. ; Sheffield, Eugene ; Swift, Dale ; Bruce, Derek. / Early diagnosis of subependymal giant cell astocytoma in patients with tuberous sclerosis. In: Journal of Child Neurology. 1998 ; Vol. 13, No. 4. pp. 173-177.
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