Early iron deficiency alters sensorimotor development and brain monoamines in rats

Erica L. Unger, Tessy Paul, Laura E. Murray-Kolb, Barbara Felt, Byron Jones, John L. Beard

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Iron deficiency in human infancy reportedly leads to developmental delays and changes in neurobiology that may be irreversible. Using a rodent model, the present study examined whether dietary iron deficiency late in pregnancy and during lactation alters sensorimotor development and brain monoaminergic systems. Rats were assigned to 1 of 4 dietary treatments during gestation and lactation: 1) iron sufficient control; 2) prenatal iron deficiency beginning on gestational d 15 (G15); 3) postnatal iron deficiency beginning on postnatal d 4 (P4); 4) iron deficiency beginning on G15 followed by an iron sufficient diet on P4. Developmental milestones, open field behavior, brain iron and proteins, monoamines, and their transporters were evaluated between P6 and P21. Only G15 iron deficient rats had greater dopaminergic activity than controls as indicated by increased tyrosine hydroxylase levels, phosphorylated tyrosine hydroxylase levels, and cellular dopamine in prefrontal cortex and striatum at P15. These rats also showed delayed eye opening, ear development, and reduced locomotor activity. Iron repletion at P4 returned most measures to control levels by the time of weaning. Postnatal iron deficiency reduced striatal and ventral midbrain iron as well as cellular dopamine levels in prefrontal cortex and striatum at P21. Developmental delays in ear development and achievement in bar holding and surface righting also resulted from postnatal iron deficiency. These results indicate that iron deficiency begun at G15 affects early dopamine neurobiology, the development of specific developmental milestones, and behavior in preweaned rats.

Original languageEnglish (US)
Pages (from-to)118-124
Number of pages7
JournalJournal of Nutrition
Volume137
Issue number1
StatePublished - Jan 2007
Externally publishedYes

Fingerprint

monoamines
Iron
iron
brain
rats
Brain
tyrosine 3-monooxygenase
dopamine
Dopamine
Neurobiology
neurophysiology
Tyrosine 3-Monooxygenase
Prefrontal Cortex
Lactation
Ear
ears
lactation
Dietary Iron
pregnancy
Corpus Striatum

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Food Science

Cite this

Unger, E. L., Paul, T., Murray-Kolb, L. E., Felt, B., Jones, B., & Beard, J. L. (2007). Early iron deficiency alters sensorimotor development and brain monoamines in rats. Journal of Nutrition, 137(1), 118-124.

Early iron deficiency alters sensorimotor development and brain monoamines in rats. / Unger, Erica L.; Paul, Tessy; Murray-Kolb, Laura E.; Felt, Barbara; Jones, Byron; Beard, John L.

In: Journal of Nutrition, Vol. 137, No. 1, 01.2007, p. 118-124.

Research output: Contribution to journalArticle

Unger, EL, Paul, T, Murray-Kolb, LE, Felt, B, Jones, B & Beard, JL 2007, 'Early iron deficiency alters sensorimotor development and brain monoamines in rats', Journal of Nutrition, vol. 137, no. 1, pp. 118-124.
Unger EL, Paul T, Murray-Kolb LE, Felt B, Jones B, Beard JL. Early iron deficiency alters sensorimotor development and brain monoamines in rats. Journal of Nutrition. 2007 Jan;137(1):118-124.
Unger, Erica L. ; Paul, Tessy ; Murray-Kolb, Laura E. ; Felt, Barbara ; Jones, Byron ; Beard, John L. / Early iron deficiency alters sensorimotor development and brain monoamines in rats. In: Journal of Nutrition. 2007 ; Vol. 137, No. 1. pp. 118-124.
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