Early mortality in acute myeloid leukemia

Andrew Hahn, Smith Giri, George Yaghmour, Michael Martin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The Southwest Oncology Group (SWOG) described the expected early mortality rate (EMR) for patients with non-M3 AML by age enrolled in clinical trials, but it is unclear how generalizable this data is. We sought to compare SWOG's reported EMR to that of the general population by utilizing the case listing session of SEER 18 matched to the accrual periods of the SWOG studies. 26,272 patients were identified within SEER compared to 968 in the SWOG cohort with mortality data. The EMR was 26.7% (7022 events) in the SEER cohort versus 12.2% (116) in the SWOG cohort. The EMR was higher in the SEER cohort in every studied age group and definition of EMR. Stepwise logistic regression analysis identified increasing age, black race (OR 1.15, CI 1.03-1.29, p. <. 0.01), and monocytic differentiation (OR 1.55, CI 1.27-1.89, p. <. 0.01) as predictors of higher EMR. This study demonstrates that EMR in patients with non-M3 AML is higher in the general patient population than reported in SWOG clinical trials.

Original languageEnglish (US)
Pages (from-to)505-509
Number of pages5
JournalLeukemia Research
Volume39
Issue number5
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Acute Myeloid Leukemia
Mortality
Clinical Trials
Population
Age Groups
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Hematology
  • Oncology
  • Medicine(all)

Cite this

Early mortality in acute myeloid leukemia. / Hahn, Andrew; Giri, Smith; Yaghmour, George; Martin, Michael.

In: Leukemia Research, Vol. 39, No. 5, 01.01.2015, p. 505-509.

Research output: Contribution to journalArticle

Hahn, Andrew ; Giri, Smith ; Yaghmour, George ; Martin, Michael. / Early mortality in acute myeloid leukemia. In: Leukemia Research. 2015 ; Vol. 39, No. 5. pp. 505-509.
@article{6d28e74c096e4e00864c1492d0c087b3,
title = "Early mortality in acute myeloid leukemia",
abstract = "The Southwest Oncology Group (SWOG) described the expected early mortality rate (EMR) for patients with non-M3 AML by age enrolled in clinical trials, but it is unclear how generalizable this data is. We sought to compare SWOG's reported EMR to that of the general population by utilizing the case listing session of SEER 18 matched to the accrual periods of the SWOG studies. 26,272 patients were identified within SEER compared to 968 in the SWOG cohort with mortality data. The EMR was 26.7{\%} (7022 events) in the SEER cohort versus 12.2{\%} (116) in the SWOG cohort. The EMR was higher in the SEER cohort in every studied age group and definition of EMR. Stepwise logistic regression analysis identified increasing age, black race (OR 1.15, CI 1.03-1.29, p. <. 0.01), and monocytic differentiation (OR 1.55, CI 1.27-1.89, p. <. 0.01) as predictors of higher EMR. This study demonstrates that EMR in patients with non-M3 AML is higher in the general patient population than reported in SWOG clinical trials.",
author = "Andrew Hahn and Smith Giri and George Yaghmour and Michael Martin",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/j.leukres.2015.02.003",
language = "English (US)",
volume = "39",
pages = "505--509",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Early mortality in acute myeloid leukemia

AU - Hahn, Andrew

AU - Giri, Smith

AU - Yaghmour, George

AU - Martin, Michael

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The Southwest Oncology Group (SWOG) described the expected early mortality rate (EMR) for patients with non-M3 AML by age enrolled in clinical trials, but it is unclear how generalizable this data is. We sought to compare SWOG's reported EMR to that of the general population by utilizing the case listing session of SEER 18 matched to the accrual periods of the SWOG studies. 26,272 patients were identified within SEER compared to 968 in the SWOG cohort with mortality data. The EMR was 26.7% (7022 events) in the SEER cohort versus 12.2% (116) in the SWOG cohort. The EMR was higher in the SEER cohort in every studied age group and definition of EMR. Stepwise logistic regression analysis identified increasing age, black race (OR 1.15, CI 1.03-1.29, p. <. 0.01), and monocytic differentiation (OR 1.55, CI 1.27-1.89, p. <. 0.01) as predictors of higher EMR. This study demonstrates that EMR in patients with non-M3 AML is higher in the general patient population than reported in SWOG clinical trials.

AB - The Southwest Oncology Group (SWOG) described the expected early mortality rate (EMR) for patients with non-M3 AML by age enrolled in clinical trials, but it is unclear how generalizable this data is. We sought to compare SWOG's reported EMR to that of the general population by utilizing the case listing session of SEER 18 matched to the accrual periods of the SWOG studies. 26,272 patients were identified within SEER compared to 968 in the SWOG cohort with mortality data. The EMR was 26.7% (7022 events) in the SEER cohort versus 12.2% (116) in the SWOG cohort. The EMR was higher in the SEER cohort in every studied age group and definition of EMR. Stepwise logistic regression analysis identified increasing age, black race (OR 1.15, CI 1.03-1.29, p. <. 0.01), and monocytic differentiation (OR 1.55, CI 1.27-1.89, p. <. 0.01) as predictors of higher EMR. This study demonstrates that EMR in patients with non-M3 AML is higher in the general patient population than reported in SWOG clinical trials.

UR - http://www.scopus.com/inward/record.url?scp=84928068433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928068433&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2015.02.003

DO - 10.1016/j.leukres.2015.02.003

M3 - Article

VL - 39

SP - 505

EP - 509

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 5

ER -