Early orchiopexy

Prepubertal intratubular germ cell neoplasia and fertility outcome

Daniel S. Engeler, Paul O. Hösli, Hubert John, Fridolin Bannwart, Tullio Sulser, Mahul Amin, Philipp U. Heitz, Seife Hailemariam

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Objectives. To investigate the prepubertal prevalence of intratubular germ cell neoplasia of the unclassified type (ITGCNU) and its significance as a predictor of testicular cancer and to evaluate the effect of early orchiopexy (at younger than 2 years of age) on subsequent fertility of patients with bilateral cryptorchidism. Methods. Testicular biopsies (n = 660) from 440 prepubertal patients with cryptorchidism who underwent orchiopexy between January 1, 1970 and December 31, 1979 were evaluated for ITGCNU using placental-like alkaline phosphatase (PLAP) antibody. The clinical outcome in 15 patients with PLAP-positive germ cells was evaluated in 1997. In addition, the effect of age at surgery on the fertility of patients with bilateral cryptorchidism was assessed by clinical follow-up until 1997 and was correlated with the histologic data at orchiopexy. Results. PLAP-positive germ cells morphologically identical with adult ITGCNU were found in the biopsies of 22 patients (5%). After more than two decades, none of the 15 patients with successful follow-up developed testicular cancer. The fertility outcome in the patients with bilateral cryptorchidism correlated with the number of spermatogonia at orchiopexy (P = 0.018), but correlated inversely with age at orchiopexy (P = 0.021). Conclusions. PLAP- positive germ cells in prepubertal testicular biopsy specimens are not necessarily precursors of testicular cancer after orchiopexy. In addition, our data support the idea that early orchiopexy may be beneficial in preventing infertility. (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)144-148
Number of pages5
JournalUrology
Volume56
Issue number1
DOIs
StatePublished - Jul 1 2000
Externally publishedYes

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Orchiopexy
Germ Cells
Fertility
Cryptorchidism
Testicular Neoplasms
Neoplasms
Biopsy
Spermatogonia
Infertility
germ-cell AP isoenzyme
Antibodies

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Engeler, D. S., Hösli, P. O., John, H., Bannwart, F., Sulser, T., Amin, M., ... Hailemariam, S. (2000). Early orchiopexy: Prepubertal intratubular germ cell neoplasia and fertility outcome. Urology, 56(1), 144-148. https://doi.org/10.1016/S0090-4295(00)00560-4

Early orchiopexy : Prepubertal intratubular germ cell neoplasia and fertility outcome. / Engeler, Daniel S.; Hösli, Paul O.; John, Hubert; Bannwart, Fridolin; Sulser, Tullio; Amin, Mahul; Heitz, Philipp U.; Hailemariam, Seife.

In: Urology, Vol. 56, No. 1, 01.07.2000, p. 144-148.

Research output: Contribution to journalArticle

Engeler, DS, Hösli, PO, John, H, Bannwart, F, Sulser, T, Amin, M, Heitz, PU & Hailemariam, S 2000, 'Early orchiopexy: Prepubertal intratubular germ cell neoplasia and fertility outcome', Urology, vol. 56, no. 1, pp. 144-148. https://doi.org/10.1016/S0090-4295(00)00560-4
Engeler, Daniel S. ; Hösli, Paul O. ; John, Hubert ; Bannwart, Fridolin ; Sulser, Tullio ; Amin, Mahul ; Heitz, Philipp U. ; Hailemariam, Seife. / Early orchiopexy : Prepubertal intratubular germ cell neoplasia and fertility outcome. In: Urology. 2000 ; Vol. 56, No. 1. pp. 144-148.
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