Editorial

How much Do PPIs contribute to C. difficile infections

Grigorios I. Leontiadis, Mark A. Miller, Colin Howden

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Two separate systematic reviews and meta-analyses published in this edition of the American Journal of Gastroenterology conclude that proton pump inhibitor (PPI) use is associated with an 70% increase in the risk of Clostridium difficile infection (CDI). The two reviews employed different methodology but reached very similar conclusions. However, since the quality of evidence from the individual studies that were included in these analyses is relatively weak, their conclusions must be interpreted cautiously. Observational studiesand even well-conducted systematic reviews of observational studiesrarely provide adequate evidence to prove causality rather than mere association. However, given both the widespread use of PPIs and the increasing incidence and importance of CDI, it is important that this association is adequately explored.

Original languageEnglish (US)
Pages (from-to)1020-1021
Number of pages2
JournalAmerican Journal of Gastroenterology
Volume107
Issue number7
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

Fingerprint

Clostridium Infections
Clostridium difficile
Proton Pump Inhibitors
Gastroenterology
Infection
Causality
Meta-Analysis
Incidence

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Editorial : How much Do PPIs contribute to C. difficile infections. / Leontiadis, Grigorios I.; Miller, Mark A.; Howden, Colin.

In: American Journal of Gastroenterology, Vol. 107, No. 7, 01.07.2012, p. 1020-1021.

Research output: Contribution to journalReview article

Leontiadis, Grigorios I. ; Miller, Mark A. ; Howden, Colin. / Editorial : How much Do PPIs contribute to C. difficile infections. In: American Journal of Gastroenterology. 2012 ; Vol. 107, No. 7. pp. 1020-1021.
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