Editors and editing of anti-DNA receptors

Hui Li, Yufei Jiang, Eline Luning Prak, Marko Radic, Martin Weigert

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

Receptor editing is a means by which immature bone marrow B cells can become self-tolerant. Rearrangements of heavy (H) and/or light (L) chain genes are induced by encounter with autoantigens to change the specificity from self to nonself. We have developed site-directed transgenic mice (sd-tg) whose transgenes code for the H chain of antibodies that bind DNA. B cells that express the transgenic H chain associate mainly with four of the 93 functional Vκ genes of the mouse. Numerous aspartate residues that might inhibit DNA binding by the V H domain distinguish these L chain Vκ sequences, but engaging these Vκ editors often requires multiple rearrangements. Among the edited B cells is a subset of multispecific cells that express multiple receptors. One consequence of multispecificity is partial autoreactivity; these multispecific B cells may contribute to autoimmunity.

Original languageEnglish (US)
Pages (from-to)947-957
Number of pages11
JournalImmunity
Volume15
Issue number6
DOIs
StatePublished - Jan 1 2001

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B-Lymphocytes
DNA
Autoimmunity
Transgenes
Aspartic Acid
Bone Marrow Cells
Transgenic Mice
Genes
Light
DNA receptor
Antibodies

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Li, H., Jiang, Y., Prak, E. L., Radic, M., & Weigert, M. (2001). Editors and editing of anti-DNA receptors. Immunity, 15(6), 947-957. https://doi.org/10.1016/S1074-7613(01)00251-5

Editors and editing of anti-DNA receptors. / Li, Hui; Jiang, Yufei; Prak, Eline Luning; Radic, Marko; Weigert, Martin.

In: Immunity, Vol. 15, No. 6, 01.01.2001, p. 947-957.

Research output: Contribution to journalArticle

Li, H, Jiang, Y, Prak, EL, Radic, M & Weigert, M 2001, 'Editors and editing of anti-DNA receptors', Immunity, vol. 15, no. 6, pp. 947-957. https://doi.org/10.1016/S1074-7613(01)00251-5
Li, Hui ; Jiang, Yufei ; Prak, Eline Luning ; Radic, Marko ; Weigert, Martin. / Editors and editing of anti-DNA receptors. In: Immunity. 2001 ; Vol. 15, No. 6. pp. 947-957.
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