EEG and behavioral effects of Δ9-Tetrahydrocannabinol in combination with stimulant drugs in rabbits

Paul Consroe, Byron Jones, Hugh Laird

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In rabbits, Δ9-tetrahydrocannabinol (THC) at 0.5 mg/kg, i.v., was challenged with i.v. methamphetamine (0.1 mg/kg), cocaine (1 mg/kg), apomorphine (1 mg/kg), or caffeine (12.5 mg/kg), and observations were made on quantified EEG and behavior. Cortical and hippocampal alterations produced by THC were antagonized by methamphetamine, cocaine, and caffeine and only briefly by apomorphine. Postural and activity behaviors were reversed by methamphetamine and caffeine but only briefly by cocaine and apomorphine. Additionally, stereotypy resulted from the combination of THC with methamphetamine, cocaine, or apomorphine. These data indicate that the effects of THC were antagonized by stimulant drugs of which caffeine was the most effective. However, novel toxicity also resulted from the interaction of THC with catecholaminergic drugs.

Original languageEnglish (US)
Pages (from-to)47-52
Number of pages6
JournalPsychopharmacology
Volume50
Issue number1
DOIs
StatePublished - Jan 1 1976

Fingerprint

Dronabinol
Methamphetamine
Apomorphine
Electroencephalography
Caffeine
Cocaine
Rabbits
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

EEG and behavioral effects of Δ9-Tetrahydrocannabinol in combination with stimulant drugs in rabbits. / Consroe, Paul; Jones, Byron; Laird, Hugh.

In: Psychopharmacology, Vol. 50, No. 1, 01.01.1976, p. 47-52.

Research output: Contribution to journalArticle

@article{6815474afbac4f048017c619a275949a,
title = "EEG and behavioral effects of Δ9-Tetrahydrocannabinol in combination with stimulant drugs in rabbits",
abstract = "In rabbits, Δ9-tetrahydrocannabinol (THC) at 0.5 mg/kg, i.v., was challenged with i.v. methamphetamine (0.1 mg/kg), cocaine (1 mg/kg), apomorphine (1 mg/kg), or caffeine (12.5 mg/kg), and observations were made on quantified EEG and behavior. Cortical and hippocampal alterations produced by THC were antagonized by methamphetamine, cocaine, and caffeine and only briefly by apomorphine. Postural and activity behaviors were reversed by methamphetamine and caffeine but only briefly by cocaine and apomorphine. Additionally, stereotypy resulted from the combination of THC with methamphetamine, cocaine, or apomorphine. These data indicate that the effects of THC were antagonized by stimulant drugs of which caffeine was the most effective. However, novel toxicity also resulted from the interaction of THC with catecholaminergic drugs.",
author = "Paul Consroe and Byron Jones and Hugh Laird",
year = "1976",
month = "1",
day = "1",
doi = "10.1007/BF00634153",
language = "English (US)",
volume = "50",
pages = "47--52",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - EEG and behavioral effects of Δ9-Tetrahydrocannabinol in combination with stimulant drugs in rabbits

AU - Consroe, Paul

AU - Jones, Byron

AU - Laird, Hugh

PY - 1976/1/1

Y1 - 1976/1/1

N2 - In rabbits, Δ9-tetrahydrocannabinol (THC) at 0.5 mg/kg, i.v., was challenged with i.v. methamphetamine (0.1 mg/kg), cocaine (1 mg/kg), apomorphine (1 mg/kg), or caffeine (12.5 mg/kg), and observations were made on quantified EEG and behavior. Cortical and hippocampal alterations produced by THC were antagonized by methamphetamine, cocaine, and caffeine and only briefly by apomorphine. Postural and activity behaviors were reversed by methamphetamine and caffeine but only briefly by cocaine and apomorphine. Additionally, stereotypy resulted from the combination of THC with methamphetamine, cocaine, or apomorphine. These data indicate that the effects of THC were antagonized by stimulant drugs of which caffeine was the most effective. However, novel toxicity also resulted from the interaction of THC with catecholaminergic drugs.

AB - In rabbits, Δ9-tetrahydrocannabinol (THC) at 0.5 mg/kg, i.v., was challenged with i.v. methamphetamine (0.1 mg/kg), cocaine (1 mg/kg), apomorphine (1 mg/kg), or caffeine (12.5 mg/kg), and observations were made on quantified EEG and behavior. Cortical and hippocampal alterations produced by THC were antagonized by methamphetamine, cocaine, and caffeine and only briefly by apomorphine. Postural and activity behaviors were reversed by methamphetamine and caffeine but only briefly by cocaine and apomorphine. Additionally, stereotypy resulted from the combination of THC with methamphetamine, cocaine, or apomorphine. These data indicate that the effects of THC were antagonized by stimulant drugs of which caffeine was the most effective. However, novel toxicity also resulted from the interaction of THC with catecholaminergic drugs.

UR - http://www.scopus.com/inward/record.url?scp=0017086787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017086787&partnerID=8YFLogxK

U2 - 10.1007/BF00634153

DO - 10.1007/BF00634153

M3 - Article

VL - 50

SP - 47

EP - 52

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 1

ER -