Effect of adjuvant radiotherapy on survival in patients with locoregional urothelial malignancies of the upper urinary tract

Andrew W. Hahn, Smith Giri, Ranjan Pathak, Vijaya Raj Bhatt, Michael Martin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: While radical nephroureterectomy is the treatment of choice for localized or regional urothelial carcinoma of the upper urinary tract (UTUC), the role of adjuvant radiotherapy is unclear, with conflicting data from various small studies. Patients and Methods: We sought to study the impact of adjuvant radiotherapy on UTUC by utilizing the Survelliance, Epidemiolgy, and End Results (SEER) 9 database from 1998-2011. Results: Of 2,572 identified cases, 113 patients (4.4%) received adjuvant radiotherapy, with a median age of 74 years (range=22-100 years). In univariate analysis, patients treated with adjuvant radiation therapy seemed to have a lower survival time than those without radiation therapy (19 months versus 31 months, p<0.05). However, after adjusting for covariates, including age at diagnosis, gender, race, year of diagnosis, stage, histological grade and surgery, radiation therapy did not seem to influence survival (hazard ratio=0.68; 95% confidence interval=0.68-1.06, p=0.85). Conclusion: This hypothesis-generating, population-based analysis shows that adjuvant radiotherapy may not influence survival among patients with locoregional UTUC.

Original languageEnglish (US)
Pages (from-to)4051-4055
Number of pages5
JournalAnticancer Research
Volume36
Issue number8
StatePublished - Aug 1 2016

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Adjuvant Radiotherapy
Urinary Tract
Radiotherapy
Survival
Neoplasms
Databases
Confidence Intervals
Carcinoma
Population
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Effect of adjuvant radiotherapy on survival in patients with locoregional urothelial malignancies of the upper urinary tract. / Hahn, Andrew W.; Giri, Smith; Pathak, Ranjan; Bhatt, Vijaya Raj; Martin, Michael.

In: Anticancer Research, Vol. 36, No. 8, 01.08.2016, p. 4051-4055.

Research output: Contribution to journalArticle

Hahn, Andrew W. ; Giri, Smith ; Pathak, Ranjan ; Bhatt, Vijaya Raj ; Martin, Michael. / Effect of adjuvant radiotherapy on survival in patients with locoregional urothelial malignancies of the upper urinary tract. In: Anticancer Research. 2016 ; Vol. 36, No. 8. pp. 4051-4055.
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