Effect of albumin supplementation during parenteral nutrition on hospital morbidity

R. O. Brown, J. E. Bradley, W. B. Bekemeyer, R. W. Luther

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Abstract

Because several studies have shown a significant inverse correlation between depressed serum concentrations of albumin and hospital morbidity, a study with central total parenteral nutrition (TPN) with normal serum albumin (NSA) in hypoalbuminemic patients was conducted. Sixty-one patients who required central TPN were randomized into one of two groups: group 1 (n = 31) received TPN plus NSA (25 to 37.5 g/day) until their measured serum albumin was >3 g/dl, and group 2 (n = 30), who received TPN alone. All patients were followed for hospital complications until discharge or death. The groups were well matched for age, sex, major diagnoses, initial serum albumin concentrations, hospital complications before TPN, and number of operative procedures. Both groups received comparable doses of energy (37.2 ± 8.9 vs. 33.0 ± 6.2 kcal/kg·day) and protein (1.6 ± 0.4 vs. 1.6 ± 0.3 g/kg·day). After initiation of TPN, there were significantly more hospital complications in group 2 (1 = 1.1 ± 1.4, n = 33; 2 = 2.6 ± 3.0, n = 80, p < .01). When complications in the patient groups were stratified, significantly more patients in group 2 developed pneumonia (18 vs. 9, p < .05) and septicemia (11 vs. 2, p < .05). Increasing serum albumin concentrations with NSA in hypoalbuminemic patients receiving central TPN appears to be associated with a reduction in hospital morbidity.

Original languageEnglish (US)
Pages (from-to)1177-1182
Number of pages6
JournalCritical Care Medicine
Volume16
Issue number12
DOIs
StatePublished - Jan 1 1988

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Total Parenteral Nutrition
Parenteral Nutrition
Serum Albumin
Albumins
Morbidity
Operative Surgical Procedures
Sepsis
Pneumonia

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Cite this

Effect of albumin supplementation during parenteral nutrition on hospital morbidity. / Brown, R. O.; Bradley, J. E.; Bekemeyer, W. B.; Luther, R. W.

In: Critical Care Medicine, Vol. 16, No. 12, 01.01.1988, p. 1177-1182.

Research output: Contribution to journalArticle

Brown, R. O. ; Bradley, J. E. ; Bekemeyer, W. B. ; Luther, R. W. / Effect of albumin supplementation during parenteral nutrition on hospital morbidity. In: Critical Care Medicine. 1988 ; Vol. 16, No. 12. pp. 1177-1182.
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