Effect of basic fibroblast growth factor on vascularization in esophagus tissue engineering

Yashio Hori, T. Nakamura, Dai Kimura, K. Kaino, Y. Kurokawa, S. Satomi, Y. Shimizu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We carried out an experimental study to evaluate the effect of basic fibroblast growth factor (bFGF)-containing collagen gel on vascularization in esophageal tissue engineering. We compared an acellular collagen sponge scaffold and an acellular collagen gel scaffold in combination with bFGF using a canine model. The construct was implanted in the cervical esophagus and the regenerated tissue was evaluated one month after surgery. Histological analysis confirmed a significantly large amount of blood vessels in the bFGF-containing collagen gel group as compared to the collagen gel group without bFGF (bFGF (-)). However, in the collagen sponge groups, no difference was observed between the bFGF (+) group and the bFGF (-) group. These results showed that bFGF-containing collagen gel is suitable not only for an acellular scaffold for tissue engineering but also for an effective tropic factor vehicle in vivo.

Original languageEnglish (US)
Pages (from-to)241-244
Number of pages4
JournalInternational Journal of Artificial Organs
Volume26
Issue number3
StatePublished - Mar 1 2003

Fingerprint

Fibroblast Growth Factor 2
Fibroblasts
Tissue Engineering
Tissue engineering
Collagen
Esophagus
Gels
Scaffolds (biology)
Porifera
Scaffolds
Tropics
Blood vessels
Intercellular Signaling Peptides and Proteins
Surgery
Blood Vessels
Canidae
Tissue

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

Hori, Y., Nakamura, T., Kimura, D., Kaino, K., Kurokawa, Y., Satomi, S., & Shimizu, Y. (2003). Effect of basic fibroblast growth factor on vascularization in esophagus tissue engineering. International Journal of Artificial Organs, 26(3), 241-244.

Effect of basic fibroblast growth factor on vascularization in esophagus tissue engineering. / Hori, Yashio; Nakamura, T.; Kimura, Dai; Kaino, K.; Kurokawa, Y.; Satomi, S.; Shimizu, Y.

In: International Journal of Artificial Organs, Vol. 26, No. 3, 01.03.2003, p. 241-244.

Research output: Contribution to journalArticle

Hori, Y, Nakamura, T, Kimura, D, Kaino, K, Kurokawa, Y, Satomi, S & Shimizu, Y 2003, 'Effect of basic fibroblast growth factor on vascularization in esophagus tissue engineering', International Journal of Artificial Organs, vol. 26, no. 3, pp. 241-244.
Hori, Yashio ; Nakamura, T. ; Kimura, Dai ; Kaino, K. ; Kurokawa, Y. ; Satomi, S. ; Shimizu, Y. / Effect of basic fibroblast growth factor on vascularization in esophagus tissue engineering. In: International Journal of Artificial Organs. 2003 ; Vol. 26, No. 3. pp. 241-244.
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