Effect of betamethasone on fetal macrophage function

Depression of adherence of immunoglobulin-coated red blood cells

Michael Caudle, G. M. Harvert, C. A. Singhas

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this study, betamethasone was found to significantly inhibit the binding of immunoglobulin-coated O Rh-positive red cells to fetal macrophages. At a dose of 0.15 mg%, betamethasone depressed immune rosette formation to 44% of controls (p<0.01); and a dose of 0.60 mg% resulted in an average depression to 22%. This in vitro effect may reflect important alterations in in vivo immune function in infants delivered from mothers who have received antenatal corticosteroids.

Original languageEnglish (US)
Pages (from-to)182-184
Number of pages3
JournalAmerican Journal of Reproductive Immunology
Volume1
Issue number4
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

Fingerprint

Betamethasone
Immunoglobulins
Erythrocytes
Macrophages
Rosette Formation
Adrenal Cortex Hormones
Mothers
Depression
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Effect of betamethasone on fetal macrophage function : Depression of adherence of immunoglobulin-coated red blood cells. / Caudle, Michael; Harvert, G. M.; Singhas, C. A.

In: American Journal of Reproductive Immunology, Vol. 1, No. 4, 01.01.1981, p. 182-184.

Research output: Contribution to journalArticle

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