Effect of Clonidine Therapy on Renal Hemodynamics in Renal Transplant Hypertension

Sandra Green, Edward T. Zawada, Wael Muakkassa, Michael Johnson, Thomas Mackenzie, Mark Mcclanahan, Ann Graybill, Mitchell Goldman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Antihypertensive medications have a variable effect on renal hemodynamics and may contribute to renal insufficiency in some patients. Since clonidine has actually been found to Improve renal hemodynamics in patients with essential hypertension, we studied the effects of clonidine therapy in patients with renal transplant hypertension. Baseline measurements of BP and renal hemodynamics were made in six patients after two weeks of therapy with furosemide. Clonidine was then added and titrated until BP was controlled. Repeated measurements of renal hemodynamics were made four and 16 weeks after clonidine therapy was begun. Glomerular filtration and effective renal plasma flow as assessed by inulin and aminohippurate sodium clearances were preserved during prolonged clonidine therapy.

Original languageEnglish (US)
Pages (from-to)1205-1208
Number of pages4
JournalArchives of Internal Medicine
Volume144
Issue number6
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Renal Hypertension
Clonidine
Hemodynamics
Transplants
Kidney
Effective Renal Plasma Flow
p-Aminohippuric Acid
Therapeutics
Inulin
Furosemide
Antihypertensive Agents
Renal Insufficiency

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Effect of Clonidine Therapy on Renal Hemodynamics in Renal Transplant Hypertension. / Green, Sandra; Zawada, Edward T.; Muakkassa, Wael; Johnson, Michael; Mackenzie, Thomas; Mcclanahan, Mark; Graybill, Ann; Goldman, Mitchell.

In: Archives of Internal Medicine, Vol. 144, No. 6, 01.01.1984, p. 1205-1208.

Research output: Contribution to journalArticle

Green, S, Zawada, ET, Muakkassa, W, Johnson, M, Mackenzie, T, Mcclanahan, M, Graybill, A & Goldman, M 1984, 'Effect of Clonidine Therapy on Renal Hemodynamics in Renal Transplant Hypertension', Archives of Internal Medicine, vol. 144, no. 6, pp. 1205-1208. https://doi.org/10.1001/archinte.1984.00350180125019
Green S, Zawada ET, Muakkassa W, Johnson M, Mackenzie T, Mcclanahan M et al. Effect of Clonidine Therapy on Renal Hemodynamics in Renal Transplant Hypertension. Archives of Internal Medicine. 1984 Jan 1;144(6):1205-1208. https://doi.org/10.1001/archinte.1984.00350180125019
Green, Sandra ; Zawada, Edward T. ; Muakkassa, Wael ; Johnson, Michael ; Mackenzie, Thomas ; Mcclanahan, Mark ; Graybill, Ann ; Goldman, Mitchell. / Effect of Clonidine Therapy on Renal Hemodynamics in Renal Transplant Hypertension. In: Archives of Internal Medicine. 1984 ; Vol. 144, No. 6. pp. 1205-1208.
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