Effect of cyclophosphamide, hydrocortisone, and levamisole on collagen‐induced arthritis in rats

John Stuart, Linda Myers, Alexander S. Townes, Andrew Kang

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The immune response of rats to type II collagen was modified by pretreating the rats with levamisole, hydrocortisone, or cyclophosphamide. Rats were observed for the development of collagen‐induced arthritis and were bled serially for the determination of antibody levels to type II collagen. Levamisole had a slight but not significant potentiating effect with arthritis developing earlier, whereas hydrocortisone and cyclophosphamide significantly depressed the incidence of arthritis; cyclophosphamide also delayed its onset. Antibody levels measured by radioimmunoassay paralleled the clinical course of arthritis.

Original languageEnglish (US)
Pages (from-to)790-794
Number of pages5
JournalArthritis & Rheumatism
Volume24
Issue number6
DOIs
StatePublished - Jan 1 1981

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Levamisole
Cyclophosphamide
Arthritis
Hydrocortisone
Collagen Type II
Antibodies
Radioimmunoassay
Incidence

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Effect of cyclophosphamide, hydrocortisone, and levamisole on collagen‐induced arthritis in rats. / Stuart, John; Myers, Linda; Townes, Alexander S.; Kang, Andrew.

In: Arthritis & Rheumatism, Vol. 24, No. 6, 01.01.1981, p. 790-794.

Research output: Contribution to journalArticle

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