Effect of disease states on theophylline serum concentrations: Are we still vigilant?

Timothy H. Self, Carol C. Chafin, Judith E. Soberman

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

The use of theophylline has decreased over the past decade because of concerns over the risks of serious adverse effects as well as availability of more effective, safer drugs. Because of this decline in use, some clinicians may not be alert to the marked effect of some disease states on theophylline serum concentrations. The purpose of this review is to heighten awareness of the effect of decompensated heart failure, cor pulmonale, hepatic dysfunction, thyroid disease, and febrile illness on theophylline serum concentrations. Because many patients receive some benefit from this drug, safe use by clinicians requires closer monitoring of serum concentrations in patients with factors that alter theophylline clearance, including several disease states.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume319
Issue number3
StatePublished - Jan 1 2000

Fingerprint

Theophylline
Serum
Pulmonary Heart Disease
Thyroid Diseases
Pharmaceutical Preparations
Fever
Heart Failure
Liver

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Effect of disease states on theophylline serum concentrations : Are we still vigilant? / Self, Timothy H.; Chafin, Carol C.; Soberman, Judith E.

In: American Journal of the Medical Sciences, Vol. 319, No. 3, 01.01.2000, p. 177-182.

Research output: Contribution to journalReview article

Self, Timothy H. ; Chafin, Carol C. ; Soberman, Judith E. / Effect of disease states on theophylline serum concentrations : Are we still vigilant?. In: American Journal of the Medical Sciences. 2000 ; Vol. 319, No. 3. pp. 177-182.
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