Effect of Domperidone, an Extracerebral Inhibitor of Dopamine Receptors, on Thyrotropin, Prolactin, Renin, Aldosterone, and 18-Hydroxycorticosterone Secretion in Man

James R. Sowers, Burt Sharp, Richard W. McCallum

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

This study investigates the dopaminergic mechanisms involved in the control of corticosteroid secretion in normal subjects. TSH, PRL, PRA, aldosterone, and 18-hydroxycorticosterone (18-OHB) were measured before and after the administration of domperidone (10 mg, iv) to eight healthy males. Domperidone, a selective peripheral dopamine antagonist, stimulated TSH and PRL secretion. Plasma concentrations of aldosterone, 18-OHB, cortisol, and PRA were not altered by domperidone. This is in contrast to previous observations of aldosterone, 18-OHB, and PRA responses to metoclopramide, a dopamine antagonist which readily crosses the blood-brain barrier. Domperidone may fail to stimulate aldosterone, 18-OHB, and renin secretion because it does not cross the blood-brain barrier or does not function as an antagonist for adrenal dopamine receptors modulating 18-OHB and aldosterone secretion.

Original languageEnglish (US)
Pages (from-to)869-871
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume54
Issue number4
DOIs
StatePublished - 1982

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18-Hydroxycorticosterone
Domperidone
Dopamine Receptors
Thyrotropin
Aldosterone
Renin
Prolactin
Dopamine Antagonists
Blood-Brain Barrier
Metoclopramide
Hydrocortisone
Adrenal Cortex Hormones
Plasmas

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

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abstract = "This study investigates the dopaminergic mechanisms involved in the control of corticosteroid secretion in normal subjects. TSH, PRL, PRA, aldosterone, and 18-hydroxycorticosterone (18-OHB) were measured before and after the administration of domperidone (10 mg, iv) to eight healthy males. Domperidone, a selective peripheral dopamine antagonist, stimulated TSH and PRL secretion. Plasma concentrations of aldosterone, 18-OHB, cortisol, and PRA were not altered by domperidone. This is in contrast to previous observations of aldosterone, 18-OHB, and PRA responses to metoclopramide, a dopamine antagonist which readily crosses the blood-brain barrier. Domperidone may fail to stimulate aldosterone, 18-OHB, and renin secretion because it does not cross the blood-brain barrier or does not function as an antagonist for adrenal dopamine receptors modulating 18-OHB and aldosterone secretion.",
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AU - Sharp, Burt

AU - McCallum, Richard W.

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