Effect of external whole body X irradiation on gallium 67 retention in mouse tissues

D. C. Swartzendruber, Karl Hubner

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Whole body and tissue retention of the radionuclide, gallium 67 (67Ga), was determined in adult C3BF1 mice after acute whole body x irradiation. A significant decrease in whole body retention occurred after an exposure to 75 R. Decreased retention in soft tissues was a transitory effect and recovery of the ability to concentrate 67Ga was dose dependent within the range of 100 to 950 R exposures. 'Recovery' occurred at Day 3 after 100 R, and between Days 6 and 8 after 450 and 950 R. The radiation effect of decreased retention was most severe when the radionuclide was administered 24 hr after irradiation. In contrast to decreased uptake in soft tissues, 67Ga concentration in whole femur increased after irradiation. Blood levels decreased rapidly in irradiated mice (67Ga injected 24 hr after 450 R) between 1 and 2 hr after administration of the radionuclide. Two hours after injection, its concentration was approximately 15% of that in nonirradiated, control animals. It is concluded that decreased 67Ga retention in mice after x irradiation is in part due to an effect on a relatively radiosensitive, as yet unidentified blood or serum component that normally binds the radioisotope.

Original languageEnglish (US)
Pages (from-to)457-468
Number of pages12
JournalRadiation Research
Volume55
Issue number3
DOIs
StatePublished - Jan 1 1973
Externally publishedYes

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Gallium
Whole-Body Irradiation
Radioisotopes
gallium
mice
irradiation
radioactive isotopes
blood
recovery
Radiation Effects
femur
Femur
radiation effects
serums
animals
Injections
injection
dosage
Serum

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

Cite this

Effect of external whole body X irradiation on gallium 67 retention in mouse tissues. / Swartzendruber, D. C.; Hubner, Karl.

In: Radiation Research, Vol. 55, No. 3, 01.01.1973, p. 457-468.

Research output: Contribution to journalArticle

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abstract = "Whole body and tissue retention of the radionuclide, gallium 67 (67Ga), was determined in adult C3BF1 mice after acute whole body x irradiation. A significant decrease in whole body retention occurred after an exposure to 75 R. Decreased retention in soft tissues was a transitory effect and recovery of the ability to concentrate 67Ga was dose dependent within the range of 100 to 950 R exposures. 'Recovery' occurred at Day 3 after 100 R, and between Days 6 and 8 after 450 and 950 R. The radiation effect of decreased retention was most severe when the radionuclide was administered 24 hr after irradiation. In contrast to decreased uptake in soft tissues, 67Ga concentration in whole femur increased after irradiation. Blood levels decreased rapidly in irradiated mice (67Ga injected 24 hr after 450 R) between 1 and 2 hr after administration of the radionuclide. Two hours after injection, its concentration was approximately 15{\%} of that in nonirradiated, control animals. It is concluded that decreased 67Ga retention in mice after x irradiation is in part due to an effect on a relatively radiosensitive, as yet unidentified blood or serum component that normally binds the radioisotope.",
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N2 - Whole body and tissue retention of the radionuclide, gallium 67 (67Ga), was determined in adult C3BF1 mice after acute whole body x irradiation. A significant decrease in whole body retention occurred after an exposure to 75 R. Decreased retention in soft tissues was a transitory effect and recovery of the ability to concentrate 67Ga was dose dependent within the range of 100 to 950 R exposures. 'Recovery' occurred at Day 3 after 100 R, and between Days 6 and 8 after 450 and 950 R. The radiation effect of decreased retention was most severe when the radionuclide was administered 24 hr after irradiation. In contrast to decreased uptake in soft tissues, 67Ga concentration in whole femur increased after irradiation. Blood levels decreased rapidly in irradiated mice (67Ga injected 24 hr after 450 R) between 1 and 2 hr after administration of the radionuclide. Two hours after injection, its concentration was approximately 15% of that in nonirradiated, control animals. It is concluded that decreased 67Ga retention in mice after x irradiation is in part due to an effect on a relatively radiosensitive, as yet unidentified blood or serum component that normally binds the radioisotope.

AB - Whole body and tissue retention of the radionuclide, gallium 67 (67Ga), was determined in adult C3BF1 mice after acute whole body x irradiation. A significant decrease in whole body retention occurred after an exposure to 75 R. Decreased retention in soft tissues was a transitory effect and recovery of the ability to concentrate 67Ga was dose dependent within the range of 100 to 950 R exposures. 'Recovery' occurred at Day 3 after 100 R, and between Days 6 and 8 after 450 and 950 R. The radiation effect of decreased retention was most severe when the radionuclide was administered 24 hr after irradiation. In contrast to decreased uptake in soft tissues, 67Ga concentration in whole femur increased after irradiation. Blood levels decreased rapidly in irradiated mice (67Ga injected 24 hr after 450 R) between 1 and 2 hr after administration of the radionuclide. Two hours after injection, its concentration was approximately 15% of that in nonirradiated, control animals. It is concluded that decreased 67Ga retention in mice after x irradiation is in part due to an effect on a relatively radiosensitive, as yet unidentified blood or serum component that normally binds the radioisotope.

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