Effect of fluorosis on liver cells of VC deficient and wild type mice

Wei Wei, Yan Jiao, Yonghui Ma, John Stuart, Xiudian Li, Fusheng Zhao, Lishi Wang, Dianjun Sun, Weikuan Gu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

For decades, mouse and other rodents have been used for the study of oxidative or related studies such as the effect of fluoride. It is known that rodents normally synthesize their own vitamin C (VC) due to the presence of a key enzyme in ascorbic acid synthesis, l-gulono-lactone-γ-oxidase (Gulo), while humans do not have the capacity of VC synthesis due to the deletion of most parts of the GULO gene. The spontaneous fracture (sfx) mouse recently emerged as a model for study of VC deficiency. We investigated the effect of fluoride on liver cells from wild type Balb/c and sfx mice. We found that activities of SOD, GPx, and CAT were reduced in both wild type and sfx mice; however, the amount of reduction in the sfx cells is more than that in Balb/c cells. In addition, while both cells increased MDA, the increase in the sfx cells is greater than that in Balb/c cells. Gene networks of Sod, Gpx, and Cat in the liver of humans and mice are also different. Our study suggests that reaction to fluoride in vitamin C deficient mice might be different from that of wild type mice.

Original languageEnglish (US)
Article number287464
JournalThe Scientific World Journal
Volume2014
DOIs
StatePublished - Jan 1 2014

Fingerprint

ascorbic acid
Liver
Ascorbic Acid
Fluorides
fluoride
rodent
Genes
Rodentia
gene
Lactones
Ascorbic Acid Deficiency
Spontaneous Fractures
Oxidoreductases
Gene Regulatory Networks
effect
enzyme
Cats
Enzymes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

Effect of fluorosis on liver cells of VC deficient and wild type mice. / Wei, Wei; Jiao, Yan; Ma, Yonghui; Stuart, John; Li, Xiudian; Zhao, Fusheng; Wang, Lishi; Sun, Dianjun; Gu, Weikuan.

In: The Scientific World Journal, Vol. 2014, 287464, 01.01.2014.

Research output: Contribution to journalArticle

Wei, Wei ; Jiao, Yan ; Ma, Yonghui ; Stuart, John ; Li, Xiudian ; Zhao, Fusheng ; Wang, Lishi ; Sun, Dianjun ; Gu, Weikuan. / Effect of fluorosis on liver cells of VC deficient and wild type mice. In: The Scientific World Journal. 2014 ; Vol. 2014.
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