Effect of High Calcium Diet on Magnesium, Catecholamines, and Blood Pressure of Stroke-Prone Spontaneously Hypertensive Rats

F. C. Luft, U. Ganten, D. Meyer, Helmut Steinberg, K. H. Gless, Th Unger, D. Ganten

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

To test the effect of a high dietary calcium intake on blood pressure, we fed stroke-prone spontaneously hypertensive (SHR-SP) and Wistar-Kyoto rats (WKY) diets containing (a) 0.25% Ca/0.08% Mg, (b) 4.0% Ca/0.02% Mg, and (c) 4.0% Ca/0.08% mg, beginning at 6 weeks of age. SHR-SP and WKY rats receiving 4% Ca with the lower Mg content had lower blood pressures, hypomagnesemia, and hypomagnesuria, and grew poorly. SHR-SP receiving 4% Ca and the higher Mg diet had blood pressures no different from those of rats receiving the 0.25% Ca diet, in spite of having lower body weights. Rubidium flux studies in erythrocytes were not influenced by Ca or Mg in the diets. Plasma phosphate values were moderately reduced in rats receiving 4% Ca diets. Epinephrine and norepinephrine values were higher in SHR-SP than in WKY rats. Norepinephrine increased with stress in both strains, independent of diet. Epinephrine values were lower in SHR-SP receiving the 4% Ca diets and showed less of an increase with stress compared to SHR-SP receiving the 0.25% Ca diet. After 26 weeks of diets, SHR-SP and WKY rats were given 0.9% NaCl in their drinking water. NaCl increased blood pressure in SHR-SP irrespective of Ca content of the diet. These data suggest that a high Ca diet influences Mg homeostasis and adrenal medullary function in SHR-SP. Further, SHR-SP appear resistant to any blood pressure lowering effect of Ca irrespective of NaCl intake.

Original languageEnglish (US)
Pages (from-to)474-481
Number of pages8
JournalProceedings of the Society for Experimental Biology and Medicine
Volume187
Issue number4
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Blood pressure
Inbred SHR Rats
Nutrition
Magnesium
Catecholamines
Rats
Stroke
Diet
Blood Pressure
Calcium
Inbred WKY Rats
Epinephrine
Norepinephrine
Rubidium
Dietary Calcium
Pressure effects
Drinking Water
Homeostasis
Erythrocytes
Phosphates

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Effect of High Calcium Diet on Magnesium, Catecholamines, and Blood Pressure of Stroke-Prone Spontaneously Hypertensive Rats. / Luft, F. C.; Ganten, U.; Meyer, D.; Steinberg, Helmut; Gless, K. H.; Unger, Th; Ganten, D.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 187, No. 4, 01.01.1988, p. 474-481.

Research output: Contribution to journalArticle

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