Effect of hydration on methotrexate plasma concentrations in children with acute lymphocytic leukemia

Michael Christensen, G. K. Rivera, W. R. Crom, M. L. Hancock, W. E. Evans

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Hydration and urinary alkalinization are used with high-dose methotrexate (HDMTX) to minimize renal toxicity resulting from methotrexate (MTX) precipitation in the kidney tubules. The effect of two hydration and alkalinization schedules on MTX plasma concentrations were evaluated in 100 children with acute lymhocytic leukemia (ALL) following two courses of MTX, 2 g/m2. The mean 21- and 44-hour MTX plasma concentrations were significantly lower in the group receiving the greater hydration and alkalinization schedule; 0.79 (0.90 SD) v 1.39 (1.99 SD) μmol/L for 21-hour MTX plasma concentrations, P = .01; and 0.18 (0.38 SD) v 0.25 (0.50 SD) μmol/L for 44-hour MTX plasma concentrations, P = .01. Although the overall incidence of toxic events was similar in both groups, the incidence of severe toxicity was reduced in the group that received the greater hydration and alkalinization, 6% v 16%. This study demonstrated that the amount of hydration and alkalinization can affect MTX plasma concentrations. Optimizing the hydration and alkalinization schedule is important for minimizing the incidence of severe toxicity associated with HDMTX.

Original languageEnglish (US)
Pages (from-to)797-801
Number of pages5
JournalJournal of Clinical Oncology
Volume6
Issue number5
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Methotrexate
Appointments and Schedules
Incidence
Kidney Tubules
Poisons
Leukemia
Kidney

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Effect of hydration on methotrexate plasma concentrations in children with acute lymphocytic leukemia. / Christensen, Michael; Rivera, G. K.; Crom, W. R.; Hancock, M. L.; Evans, W. E.

In: Journal of Clinical Oncology, Vol. 6, No. 5, 01.01.1988, p. 797-801.

Research output: Contribution to journalArticle

Christensen, Michael ; Rivera, G. K. ; Crom, W. R. ; Hancock, M. L. ; Evans, W. E. / Effect of hydration on methotrexate plasma concentrations in children with acute lymphocytic leukemia. In: Journal of Clinical Oncology. 1988 ; Vol. 6, No. 5. pp. 797-801.
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