Effect of indomethacin on pulmonary vascular response to ventilation of fetal goats

Charles Leffler, T. L. Tyler, S. Cassin

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The effect of indomethacin treatment on the pulmonary vasodilation caused by ventilation of the fetal lung with air was evaluated in anesthetized, exteriorized, fetal goats by means of an open-chest, pump-perfused lung preparation. The decrease in pulmonary vascular resistance that occurs when the fetal lung is ventilated with air consists of 2 components: a rapid decrease in pulmonary vascular resistance during the first 30 s of ventilation; a slower decline, which continues through the first 10-20 min or more of ventilation. Indomethacin has no effect on the first component. The second component is absent following indomethacin pretreatment. The effect of indomethacin treatment is more pronounced in immature fetuses (less than 90% gestation) than in mature fetuses. Prostaglandin synthase activity appears to be important in the pulmonary vasodilation caused by ventilation of the fetal lungs with air.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume3
Issue number4
StatePublished - Jan 1 1978
Externally publishedYes

Fingerprint

Goats
Indomethacin
Blood Vessels
Ventilation
Lung
Air
Vasodilation
Vascular Resistance
Fetus
Prostaglandin-Endoperoxide Synthases
Thorax
Pregnancy

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Effect of indomethacin on pulmonary vascular response to ventilation of fetal goats. / Leffler, Charles; Tyler, T. L.; Cassin, S.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 3, No. 4, 01.01.1978.

Research output: Contribution to journalArticle

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