Effect of interleukin-6 deficiency on the formation of periapical lesions after pulp exposure in mice

George Huang, Michael Do, Margaret Wingard, Jin S. Park, Nadia Chugal

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objective. The multifunctional cytokine interleukin-6 (IL-6) has actions on multiple cell types, including promotion of the development of immune cells and osteoclasts. Periapical inflammation as the result of root canal infection is characterized by the accumulation of inflammatory cells and bone resorption. The effect of IL-6 on periapical lesion formation after pulpal infection is unknown. We sought to determine whether deletion of IL-6 affects periapical lesion formation after pulp exposure. Methods. Molar pulps of homozygous IL-6 knock-out mice (IL-6-/-, strain B6, 129-//6tm1Koe) and wild-type mice (IL-6+/+) were exposed, and the mice were killed at 1, 2, 3, 5, and 8 weeks after the exposure. Mouse jaws were decalcified and prepared for histologic examination of periapical lesions. Results. The IL-6-/- mice developed larger periapical lesions more rapidly than did the IL-6+/+ mice. Conclusions. IL-6 deletion promoted periapical lesion development.

Original languageEnglish (US)
Pages (from-to)83-88
Number of pages6
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume92
Issue number1
DOIs
StatePublished - Jan 1 2001

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Interleukin-6
Dental Pulp Cavity
Osteoclasts
Bone Resorption
Infection
Jaw
Knockout Mice
Cytokines
Inflammation
mouse interleukin-6

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

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Effect of interleukin-6 deficiency on the formation of periapical lesions after pulp exposure in mice. / Huang, George; Do, Michael; Wingard, Margaret; Park, Jin S.; Chugal, Nadia.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 92, No. 1, 01.01.2001, p. 83-88.

Research output: Contribution to journalArticle

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abstract = "Objective. The multifunctional cytokine interleukin-6 (IL-6) has actions on multiple cell types, including promotion of the development of immune cells and osteoclasts. Periapical inflammation as the result of root canal infection is characterized by the accumulation of inflammatory cells and bone resorption. The effect of IL-6 on periapical lesion formation after pulpal infection is unknown. We sought to determine whether deletion of IL-6 affects periapical lesion formation after pulp exposure. Methods. Molar pulps of homozygous IL-6 knock-out mice (IL-6-/-, strain B6, 129-//6tm1Koe) and wild-type mice (IL-6+/+) were exposed, and the mice were killed at 1, 2, 3, 5, and 8 weeks after the exposure. Mouse jaws were decalcified and prepared for histologic examination of periapical lesions. Results. The IL-6-/- mice developed larger periapical lesions more rapidly than did the IL-6+/+ mice. Conclusions. IL-6 deletion promoted periapical lesion development.",
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AU - Wingard, Margaret

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AU - Chugal, Nadia

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N2 - Objective. The multifunctional cytokine interleukin-6 (IL-6) has actions on multiple cell types, including promotion of the development of immune cells and osteoclasts. Periapical inflammation as the result of root canal infection is characterized by the accumulation of inflammatory cells and bone resorption. The effect of IL-6 on periapical lesion formation after pulpal infection is unknown. We sought to determine whether deletion of IL-6 affects periapical lesion formation after pulp exposure. Methods. Molar pulps of homozygous IL-6 knock-out mice (IL-6-/-, strain B6, 129-//6tm1Koe) and wild-type mice (IL-6+/+) were exposed, and the mice were killed at 1, 2, 3, 5, and 8 weeks after the exposure. Mouse jaws were decalcified and prepared for histologic examination of periapical lesions. Results. The IL-6-/- mice developed larger periapical lesions more rapidly than did the IL-6+/+ mice. Conclusions. IL-6 deletion promoted periapical lesion development.

AB - Objective. The multifunctional cytokine interleukin-6 (IL-6) has actions on multiple cell types, including promotion of the development of immune cells and osteoclasts. Periapical inflammation as the result of root canal infection is characterized by the accumulation of inflammatory cells and bone resorption. The effect of IL-6 on periapical lesion formation after pulpal infection is unknown. We sought to determine whether deletion of IL-6 affects periapical lesion formation after pulp exposure. Methods. Molar pulps of homozygous IL-6 knock-out mice (IL-6-/-, strain B6, 129-//6tm1Koe) and wild-type mice (IL-6+/+) were exposed, and the mice were killed at 1, 2, 3, 5, and 8 weeks after the exposure. Mouse jaws were decalcified and prepared for histologic examination of periapical lesions. Results. The IL-6-/- mice developed larger periapical lesions more rapidly than did the IL-6+/+ mice. Conclusions. IL-6 deletion promoted periapical lesion development.

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