Effect of isolated hepatic ischemia on organic anion clearance and oxidative metabolism

Gayle Minard, Timothy Fabian, Martin Croce, Kenneth A. Kudsk, George C. Wood, Raymond Bynoe

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hepatic failure is frequently seen following severe hemorrhagic shock, sepsis, and trauma. Clearance of various drugs has been used to evaluate hepatocellular dysfunction, including indocyanine green (ICG), an organic anionic dye that is transported similarly to bilirubin, and antipyrine (AP), a marker of oxidative phosphorylation. Previous investigators have noted a decrease in ICG excretion following systemic hemorrhage. The effect of isolated hepatic ischemia on the clearances of ICG and AP was studied in 16 pigs after 90 minutes of vascular occlusion to the liver. Antipyrine clearance decreased almost 50% from baseline values at 24 and 72 hours after the ischemia procedure, indicating a significant depression in the cytochrome P- 450 system. On the other hand, ICG clearance did not change significantly. In conclusion, ICG clearance is not depressed after isolated hepatic ischemia in pigs. Changes in organic anion clearance after systemic hemorrhage may be because of release of toxic products from ischemic peripheral tissue.

Original languageEnglish (US)
Pages (from-to)514-519
Number of pages6
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume32
Issue number4
DOIs
StatePublished - Jan 1 1992

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Indocyanine Green
Anions
Antipyrine
Ischemia
Liver
Swine
Hemorrhage
Hemorrhagic Shock
Poisons
Oxidative Phosphorylation
Liver Failure
Bilirubin
Cytochrome P-450 Enzyme System
Blood Vessels
Sepsis
Coloring Agents
Research Personnel
Wounds and Injuries
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

Effect of isolated hepatic ischemia on organic anion clearance and oxidative metabolism. / Minard, Gayle; Fabian, Timothy; Croce, Martin; Kudsk, Kenneth A.; Wood, George C.; Bynoe, Raymond.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 32, No. 4, 01.01.1992, p. 514-519.

Research output: Contribution to journalArticle

Minard, Gayle ; Fabian, Timothy ; Croce, Martin ; Kudsk, Kenneth A. ; Wood, George C. ; Bynoe, Raymond. / Effect of isolated hepatic ischemia on organic anion clearance and oxidative metabolism. In: Journal of Trauma - Injury, Infection and Critical Care. 1992 ; Vol. 32, No. 4. pp. 514-519.
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