Effect of peptides of bovine myelin basic protein on dermal fibroblasts

T. M. Chiang, J. N. Whitaker, J. M. Seyer, Andrew Kang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Bovine basic protein (BP) was digested with purified bovine brain cathepsin D to produce well defined BP derived peptides 1–42, 43–88, 43–169, and 89–169. BP and these BP peptides were tested for their effects on cultured human dermal fibroblasts using a concentration range of 0.01–1,000 ng/ml. No effect was found on cellular proliferation, and neither total protein nor collagen synthesis was altered in the presence of these substances. Although preparations of brain which contain a fibroblast‐growth factor also contain BP peptides, these results indicate that the purified BP peptides studied have no detectable biological effect on the growth of human dermal fibroblasts.

Original languageEnglish (US)
Pages (from-to)439-445
Number of pages7
JournalJournal of Neuroscience Research
Volume5
Issue number5
DOIs
StatePublished - Jan 1 1980

Fingerprint

Myelin Basic Protein
Fibroblasts
Skin
Peptides
Proteins
Cathepsin D
Brain
Collagen
Cell Proliferation
Growth

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

Cite this

Effect of peptides of bovine myelin basic protein on dermal fibroblasts. / Chiang, T. M.; Whitaker, J. N.; Seyer, J. M.; Kang, Andrew.

In: Journal of Neuroscience Research, Vol. 5, No. 5, 01.01.1980, p. 439-445.

Research output: Contribution to journalArticle

Chiang, T. M. ; Whitaker, J. N. ; Seyer, J. M. ; Kang, Andrew. / Effect of peptides of bovine myelin basic protein on dermal fibroblasts. In: Journal of Neuroscience Research. 1980 ; Vol. 5, No. 5. pp. 439-445.
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