Effect of physical inactivity on major non-communicable diseases worldwide

An analysis of burden of disease and life expectancy

I. Min Lee, Eric J. Shiroma, Felipe Lobelo, Pekka Puska, Steven N. Blair, Peter T. Katzmarzyk, Jasem R. Alkandari, Lars Bo Andersen, Adrian E. Bauman, Ross C. Brownson, Fiona C. Bull, Cora L. Craig, Ulf Ekelund, Shifalika Goenka, Regina Guthold, Pedro C. Hallal, William L. Haskell, Gregory Heath, Shigeru Inoue, Sonja Kahlmeier & 14 others Harold W. Kohl, Estelle Victoria Lambert, Grit Leetongin, Ruth J.F. Loos, Bess Marcus, Brian W. Martin, Neville Owen, Diana C. Parra, Michael Pratt, David Ogilvie, Rodrigo S. Reis, James F. Sallis, Olga Lucia Sarmiento, Jonathan C. Wells

Research output: Contribution to journalArticle

2653 Citations (Scopus)

Abstract

Background Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including major non-communicable diseases such as coronary heart disease, type 2 diabetes, and breast and colon cancers, and shortens life expectancy. Because much of the world's population is inactive, this link presents a major public health issue. We aimed to quantify the effect of physical inactivity on these major non-communicable diseases by estimating how much disease could be averted if inactive people were to become active and to estimate gain in life expectancy at the population level. Methods For our analysis of burden of disease, we calculated population attributable fractions (PAFs) associated with physical inactivity using conservative assumptions for each of the major non-communicable diseases, by country, to estimate how much disease could be averted if physical inactivity were eliminated. We used life-table analysis to estimate gains in life expectancy of the population. Findings Worldwide, we estimate that physical inactivity causes 6% (ranging from 3.2% in southeast Asia to 7.8% in the eastern Mediterranean region) of the burden of disease from coronary heart disease, 7% (3.9-9.6) of type 2 diabetes, 10% (5.6-14.1) of breast cancer, and 10% (5.7-13.8) of colon cancer. Inactivity causes 9% (range 5.1-12.5) of premature mortality, or more than 5.3 million of the 57 million deaths that occurred worldwide in 2008. If inactivity were not eliminated, but decreased instead by 10% or 25%, more than 533 000 and more than 1.3 million deaths, respectively, could be averted every year. We estimated that elimination of physical inactivity would increase the life expectancy of the world's population by 0.68 (range 0.41-0.95) years. Interpretation Physical inactivity has a major health effect worldwide. Decrease in or removal of this unhealthy behaviour could improve health substantially. Funding None.

Original languageEnglish (US)
Pages (from-to)219-229
Number of pages11
JournalThe Lancet
Volume380
Issue number9838
DOIs
StatePublished - Jan 1 2012

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Life Expectancy
Population
Colonic Neoplasms
Type 2 Diabetes Mellitus
Coronary Disease
Breast Neoplasms
Mediterranean Region
Southeastern Asia
Premature Mortality
Life Tables
Health
Public Health

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, I. M., Shiroma, E. J., Lobelo, F., Puska, P., Blair, S. N., Katzmarzyk, P. T., ... Wells, J. C. (2012). Effect of physical inactivity on major non-communicable diseases worldwide: An analysis of burden of disease and life expectancy. The Lancet, 380(9838), 219-229. https://doi.org/10.1016/S0140-6736(12)61031-9

Effect of physical inactivity on major non-communicable diseases worldwide : An analysis of burden of disease and life expectancy. / Lee, I. Min; Shiroma, Eric J.; Lobelo, Felipe; Puska, Pekka; Blair, Steven N.; Katzmarzyk, Peter T.; Alkandari, Jasem R.; Andersen, Lars Bo; Bauman, Adrian E.; Brownson, Ross C.; Bull, Fiona C.; Craig, Cora L.; Ekelund, Ulf; Goenka, Shifalika; Guthold, Regina; Hallal, Pedro C.; Haskell, William L.; Heath, Gregory; Inoue, Shigeru; Kahlmeier, Sonja; Kohl, Harold W.; Lambert, Estelle Victoria; Leetongin, Grit; Loos, Ruth J.F.; Marcus, Bess; Martin, Brian W.; Owen, Neville; Parra, Diana C.; Pratt, Michael; Ogilvie, David; Reis, Rodrigo S.; Sallis, James F.; Sarmiento, Olga Lucia; Wells, Jonathan C.

In: The Lancet, Vol. 380, No. 9838, 01.01.2012, p. 219-229.

Research output: Contribution to journalArticle

Lee, IM, Shiroma, EJ, Lobelo, F, Puska, P, Blair, SN, Katzmarzyk, PT, Alkandari, JR, Andersen, LB, Bauman, AE, Brownson, RC, Bull, FC, Craig, CL, Ekelund, U, Goenka, S, Guthold, R, Hallal, PC, Haskell, WL, Heath, G, Inoue, S, Kahlmeier, S, Kohl, HW, Lambert, EV, Leetongin, G, Loos, RJF, Marcus, B, Martin, BW, Owen, N, Parra, DC, Pratt, M, Ogilvie, D, Reis, RS, Sallis, JF, Sarmiento, OL & Wells, JC 2012, 'Effect of physical inactivity on major non-communicable diseases worldwide: An analysis of burden of disease and life expectancy', The Lancet, vol. 380, no. 9838, pp. 219-229. https://doi.org/10.1016/S0140-6736(12)61031-9
Lee, I. Min ; Shiroma, Eric J. ; Lobelo, Felipe ; Puska, Pekka ; Blair, Steven N. ; Katzmarzyk, Peter T. ; Alkandari, Jasem R. ; Andersen, Lars Bo ; Bauman, Adrian E. ; Brownson, Ross C. ; Bull, Fiona C. ; Craig, Cora L. ; Ekelund, Ulf ; Goenka, Shifalika ; Guthold, Regina ; Hallal, Pedro C. ; Haskell, William L. ; Heath, Gregory ; Inoue, Shigeru ; Kahlmeier, Sonja ; Kohl, Harold W. ; Lambert, Estelle Victoria ; Leetongin, Grit ; Loos, Ruth J.F. ; Marcus, Bess ; Martin, Brian W. ; Owen, Neville ; Parra, Diana C. ; Pratt, Michael ; Ogilvie, David ; Reis, Rodrigo S. ; Sallis, James F. ; Sarmiento, Olga Lucia ; Wells, Jonathan C. / Effect of physical inactivity on major non-communicable diseases worldwide : An analysis of burden of disease and life expectancy. In: The Lancet. 2012 ; Vol. 380, No. 9838. pp. 219-229.
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abstract = "Background Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including major non-communicable diseases such as coronary heart disease, type 2 diabetes, and breast and colon cancers, and shortens life expectancy. Because much of the world's population is inactive, this link presents a major public health issue. We aimed to quantify the effect of physical inactivity on these major non-communicable diseases by estimating how much disease could be averted if inactive people were to become active and to estimate gain in life expectancy at the population level. Methods For our analysis of burden of disease, we calculated population attributable fractions (PAFs) associated with physical inactivity using conservative assumptions for each of the major non-communicable diseases, by country, to estimate how much disease could be averted if physical inactivity were eliminated. We used life-table analysis to estimate gains in life expectancy of the population. Findings Worldwide, we estimate that physical inactivity causes 6{\%} (ranging from 3.2{\%} in southeast Asia to 7.8{\%} in the eastern Mediterranean region) of the burden of disease from coronary heart disease, 7{\%} (3.9-9.6) of type 2 diabetes, 10{\%} (5.6-14.1) of breast cancer, and 10{\%} (5.7-13.8) of colon cancer. Inactivity causes 9{\%} (range 5.1-12.5) of premature mortality, or more than 5.3 million of the 57 million deaths that occurred worldwide in 2008. If inactivity were not eliminated, but decreased instead by 10{\%} or 25{\%}, more than 533 000 and more than 1.3 million deaths, respectively, could be averted every year. We estimated that elimination of physical inactivity would increase the life expectancy of the world's population by 0.68 (range 0.41-0.95) years. Interpretation Physical inactivity has a major health effect worldwide. Decrease in or removal of this unhealthy behaviour could improve health substantially. Funding None.",
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T2 - An analysis of burden of disease and life expectancy

AU - Lee, I. Min

AU - Shiroma, Eric J.

AU - Lobelo, Felipe

AU - Puska, Pekka

AU - Blair, Steven N.

AU - Katzmarzyk, Peter T.

AU - Alkandari, Jasem R.

AU - Andersen, Lars Bo

AU - Bauman, Adrian E.

AU - Brownson, Ross C.

AU - Bull, Fiona C.

AU - Craig, Cora L.

AU - Ekelund, Ulf

AU - Goenka, Shifalika

AU - Guthold, Regina

AU - Hallal, Pedro C.

AU - Haskell, William L.

AU - Heath, Gregory

AU - Inoue, Shigeru

AU - Kahlmeier, Sonja

AU - Kohl, Harold W.

AU - Lambert, Estelle Victoria

AU - Leetongin, Grit

AU - Loos, Ruth J.F.

AU - Marcus, Bess

AU - Martin, Brian W.

AU - Owen, Neville

AU - Parra, Diana C.

AU - Pratt, Michael

AU - Ogilvie, David

AU - Reis, Rodrigo S.

AU - Sallis, James F.

AU - Sarmiento, Olga Lucia

AU - Wells, Jonathan C.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including major non-communicable diseases such as coronary heart disease, type 2 diabetes, and breast and colon cancers, and shortens life expectancy. Because much of the world's population is inactive, this link presents a major public health issue. We aimed to quantify the effect of physical inactivity on these major non-communicable diseases by estimating how much disease could be averted if inactive people were to become active and to estimate gain in life expectancy at the population level. Methods For our analysis of burden of disease, we calculated population attributable fractions (PAFs) associated with physical inactivity using conservative assumptions for each of the major non-communicable diseases, by country, to estimate how much disease could be averted if physical inactivity were eliminated. We used life-table analysis to estimate gains in life expectancy of the population. Findings Worldwide, we estimate that physical inactivity causes 6% (ranging from 3.2% in southeast Asia to 7.8% in the eastern Mediterranean region) of the burden of disease from coronary heart disease, 7% (3.9-9.6) of type 2 diabetes, 10% (5.6-14.1) of breast cancer, and 10% (5.7-13.8) of colon cancer. Inactivity causes 9% (range 5.1-12.5) of premature mortality, or more than 5.3 million of the 57 million deaths that occurred worldwide in 2008. If inactivity were not eliminated, but decreased instead by 10% or 25%, more than 533 000 and more than 1.3 million deaths, respectively, could be averted every year. We estimated that elimination of physical inactivity would increase the life expectancy of the world's population by 0.68 (range 0.41-0.95) years. Interpretation Physical inactivity has a major health effect worldwide. Decrease in or removal of this unhealthy behaviour could improve health substantially. Funding None.

AB - Background Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including major non-communicable diseases such as coronary heart disease, type 2 diabetes, and breast and colon cancers, and shortens life expectancy. Because much of the world's population is inactive, this link presents a major public health issue. We aimed to quantify the effect of physical inactivity on these major non-communicable diseases by estimating how much disease could be averted if inactive people were to become active and to estimate gain in life expectancy at the population level. Methods For our analysis of burden of disease, we calculated population attributable fractions (PAFs) associated with physical inactivity using conservative assumptions for each of the major non-communicable diseases, by country, to estimate how much disease could be averted if physical inactivity were eliminated. We used life-table analysis to estimate gains in life expectancy of the population. Findings Worldwide, we estimate that physical inactivity causes 6% (ranging from 3.2% in southeast Asia to 7.8% in the eastern Mediterranean region) of the burden of disease from coronary heart disease, 7% (3.9-9.6) of type 2 diabetes, 10% (5.6-14.1) of breast cancer, and 10% (5.7-13.8) of colon cancer. Inactivity causes 9% (range 5.1-12.5) of premature mortality, or more than 5.3 million of the 57 million deaths that occurred worldwide in 2008. If inactivity were not eliminated, but decreased instead by 10% or 25%, more than 533 000 and more than 1.3 million deaths, respectively, could be averted every year. We estimated that elimination of physical inactivity would increase the life expectancy of the world's population by 0.68 (range 0.41-0.95) years. Interpretation Physical inactivity has a major health effect worldwide. Decrease in or removal of this unhealthy behaviour could improve health substantially. Funding None.

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