Effect of polyphloretin phosphate on the response of non-gravid rat uterus to 'folkloric' and 'standard' oxytocics in vitro

Adebowale Adebiyi, R. N.V. Prasad, P. G. Adaikan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Polyphloretin phosphate (PPP) has been reported by previous workers to be a specific antagonist of prostaglandin (PGE 1 , PGE 2 & PGF2α)-induced contractions of isolated jird colon, gerbil colon, guinea pig ileum, and rabbit jejunum. In the present study, we examined the effect of PPP on uterotonic activities of crude papaya latex (a folkloric oxytocic), PGF , oxytocin, acetylcholine, and 5-hydroxytryptamine (standard oxytocics) on non-gravid, oestrogen-primed (50 μg/kg) rats in vitro. The effect of PPP on the oxytocics was evaluated qualitatively by incubating the tissues in PPP (25 - 400 μg/ml) for 20 min prior to the addition of a constant concentration of each oxytocic. PPP concentration dependently inhibited the contractile response of the uterine muscles to all the oxytocics. The inhibition was reversible after washing out the drugs. Results of the present study suggest that PPP is a non-specific and reversible antagonist of the response of non-gravid rat uterine smooth muscle to oxytocics in vitro. The specificity of PPP as a prostaglandin antagonist could therefore be species/tissue dependent.

Original languageEnglish (US)
Pages (from-to)499-503
Number of pages5
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume66
Issue number5-6
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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Polyphloretin Phosphate
Oxytocics
Uterus
Rats
Prostaglandin Antagonists
Gerbillinae
Myometrium
Prostaglandins E
Muscle
Colon
Tissue
Carica
Dinoprost
Latex
Prostaglandins F
Oxytocin
Jejunum
In Vitro Techniques
Ileum
Washing

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Cell Biology

Cite this

Effect of polyphloretin phosphate on the response of non-gravid rat uterus to 'folkloric' and 'standard' oxytocics in vitro. / Adebiyi, Adebowale; Prasad, R. N.V.; Adaikan, P. G.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 66, No. 5-6, 01.01.2002, p. 499-503.

Research output: Contribution to journalArticle

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