Effect of positive-end expiratory pressure on accuracy of thermal-dye measurements of lung water

Blaine Enderson, Charles L. Rice, Gerald S. Moss

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The thermal-dye indicator dilution technique of measuring extravascular lung water (EVLW-TD) correlates well with gravimetric measurement of lung water (EVLW-GR) when no positive-end expiratory pressure (PEEP) is used in both normal and edematous lungs. PEEP is often used to raise arterial oxygen tension in acute respiratory failure. This study was designed to answer the question: Does PEEP have an effect on the accuracy of the EVLW measurement by thermal dye? Sixteen mongrel dogs were anesthetized and intubated. Arterial and PA catheters were placed. They were divided into three groups and ventilated at PEEP levels of 5, 10, or 15 cm H2O. Fluids were given to minimize decrease in cardiac output with institution of PEEP. They were maintained for 5 hr with measurement of vital signs made hourly and measurement of blood gases and EVLW-TD made at baseline, 1, 3, and 5 hr. After final measurements, gravimetric determination of EVLW was done. Correlation between EVLWTD and EVLWGR remained good when low levels of PEEP were used. At 5 cm H2O PEEP, EVLWTD was 7.5 ± 0.9 and EVLWGR was 5.4 ± .3. At 10 cm H2O PEEP, they were 10.0 ± 0.9 and 6.5 ± 0.3. The correlations were 0.87 and 0.97, respectively. However, at 15 cm H2O PEEP, EVLWTD was 11.4 ± 1.3 and EVLWGR was 7.5 ± 0.6, with a correlation of only 0.59. The correlation between the two techniques seems to break down with higher levels of PEEP in dogs with normal lungs.

Original languageEnglish (US)
Pages (from-to)224-230
Number of pages7
JournalJournal of Surgical Research
Volume38
Issue number3
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

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Positive-Pressure Respiration
Coloring Agents
Hot Temperature
Lung
Water
Dye Dilution Technique
Extravascular Lung Water
Dogs
Indicator Dilution Techniques
Vital Signs
Respiratory Insufficiency
Cardiac Output
Arterial Pressure
Catheters
Gases
Oxygen

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Effect of positive-end expiratory pressure on accuracy of thermal-dye measurements of lung water. / Enderson, Blaine; Rice, Charles L.; Moss, Gerald S.

In: Journal of Surgical Research, Vol. 38, No. 3, 01.01.1985, p. 224-230.

Research output: Contribution to journalArticle

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