Effect of Preexisting Serum and Mucosal Antibody on Experimental Respiratory Syncytial Virus (RSV) Challenge and Infection of Adults

Bindiya Bagga, Jeffrey E. Cehelsky, Akshay Vaishnaw, T. Tomwilkinson, Rachel Meyers, Lisa M. Harrison, Philippa L. Roddam, Edward E. Walsh, John Devincenzo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We studied preexisting respiratory syncytial virus (RSV)- specific serum and nasal antibodies and their correlation with infectivity, viral dynamics, and disease severity in a human experimental infection model. Higher preinoculation serum neutralizing antibody titers and nasal immunoglobulin (Ig) A predicted lower infectivity and lower measures of viral replication. However, once individuals were infected, no significant protective effect of preexisting antibodies was seen. Lack of correlation between serum and mucosal antibodies was observed, implying that they are independent co-correlates of protection against RSV infection. We suggest that protection from RSV infection is a function of a complex interplay between mucosal and serum humoral immune responses.

Original languageEnglish (US)
Pages (from-to)1719-1725
Number of pages7
JournalJournal of Infectious Diseases
Volume212
Issue number10
DOIs
StatePublished - Jan 1 2015

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Respiratory Syncytial Virus Infections
Antibodies
Serum
Nose
Respiratory Syncytial Viruses
Virus Diseases
Humoral Immunity
Neutralizing Antibodies
Immunoglobulin A
Theoretical Models
Infection

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Effect of Preexisting Serum and Mucosal Antibody on Experimental Respiratory Syncytial Virus (RSV) Challenge and Infection of Adults. / Bagga, Bindiya; Cehelsky, Jeffrey E.; Vaishnaw, Akshay; Tomwilkinson, T.; Meyers, Rachel; Harrison, Lisa M.; Roddam, Philippa L.; Walsh, Edward E.; Devincenzo, John.

In: Journal of Infectious Diseases, Vol. 212, No. 10, 01.01.2015, p. 1719-1725.

Research output: Contribution to journalArticle

Bagga, B, Cehelsky, JE, Vaishnaw, A, Tomwilkinson, T, Meyers, R, Harrison, LM, Roddam, PL, Walsh, EE & Devincenzo, J 2015, 'Effect of Preexisting Serum and Mucosal Antibody on Experimental Respiratory Syncytial Virus (RSV) Challenge and Infection of Adults', Journal of Infectious Diseases, vol. 212, no. 10, pp. 1719-1725. https://doi.org/10.1093/infdis/jiv281
Bagga, Bindiya ; Cehelsky, Jeffrey E. ; Vaishnaw, Akshay ; Tomwilkinson, T. ; Meyers, Rachel ; Harrison, Lisa M. ; Roddam, Philippa L. ; Walsh, Edward E. ; Devincenzo, John. / Effect of Preexisting Serum and Mucosal Antibody on Experimental Respiratory Syncytial Virus (RSV) Challenge and Infection of Adults. In: Journal of Infectious Diseases. 2015 ; Vol. 212, No. 10. pp. 1719-1725.
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