Effect of prenatal pentylenetetrazol-induced kindling on learning and memory of male offspring

A. Pourmotabbed, S. E. Nedaei, M. Cheraghi, S. Moradian, A. Touhidi, M. Aeinfar, Z. Seyfi, Tayebeh Pourmotabbed

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Abstract

Current data concerning the effects of maternal seizure during pregnancy on newborns are limited. This study was carried out to investigate the effect of prenatal pentylenetetrazol (PTZ)-induced kindling on learning and memory of offspring. Female Wistar rats were kindled with i.p. injections of 25 mg/kg of PTZ on day 13 of their pregnancy. The spatial performance and passive avoidance learning of pups were tested at 7 weeks and 12 weeks of age using Morris water maze (MWM) task and shuttle-box apparatus, respectively. We found, for the first time, that prenatal exposure to maternal seizure induced by PTZ leads to a significant impairment of learning and memory. In addition, the number of live birth was significantly lower in kindled rats compared to control. In MWM studies, the young offspring of kindled rats had poor spatial learning ability. The frequent tonic-clonic seizures in pregnancy was also associated with a poor memory as evidenced by decrease in distance swam in the target quadrant by the offspring of the kindled mother in the adulthood. Data obtained from shuttle-box studies showed that retention latencies of pups born to kindled dams were significantly reduced compared to those born to control dams. The hippocampus, amygdala and frontal cortex are very important for memory consolidation and our data suggest that subsequent developmental events are not sufficient to overcome the adverse effects of prenatal exposure to maternal seizures to these regions of the brain. These observations may have clinical implications for cognitive and memory dysfunction associated with epilepsy during pregnancy.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalNeuroscience
Volume172
DOIs
StatePublished - Jan 13 2011

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Pentylenetetrazole
Seizures
Learning
Maternal Exposure
Pregnancy
Avoidance Learning
Water
Live Birth
Frontal Lobe
Amygdala
Wistar Rats
Epilepsy
Hippocampus
Mothers
Injections
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Effect of prenatal pentylenetetrazol-induced kindling on learning and memory of male offspring. / Pourmotabbed, A.; Nedaei, S. E.; Cheraghi, M.; Moradian, S.; Touhidi, A.; Aeinfar, M.; Seyfi, Z.; Pourmotabbed, Tayebeh.

In: Neuroscience, Vol. 172, 13.01.2011, p. 205-211.

Research output: Contribution to journalArticle

Pourmotabbed, A, Nedaei, SE, Cheraghi, M, Moradian, S, Touhidi, A, Aeinfar, M, Seyfi, Z & Pourmotabbed, T 2011, 'Effect of prenatal pentylenetetrazol-induced kindling on learning and memory of male offspring', Neuroscience, vol. 172, pp. 205-211. https://doi.org/10.1016/j.neuroscience.2010.11.001
Pourmotabbed A, Nedaei SE, Cheraghi M, Moradian S, Touhidi A, Aeinfar M et al. Effect of prenatal pentylenetetrazol-induced kindling on learning and memory of male offspring. Neuroscience. 2011 Jan 13;172:205-211. https://doi.org/10.1016/j.neuroscience.2010.11.001
Pourmotabbed, A. ; Nedaei, S. E. ; Cheraghi, M. ; Moradian, S. ; Touhidi, A. ; Aeinfar, M. ; Seyfi, Z. ; Pourmotabbed, Tayebeh. / Effect of prenatal pentylenetetrazol-induced kindling on learning and memory of male offspring. In: Neuroscience. 2011 ; Vol. 172. pp. 205-211.
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