Effect of propranolol on nitrogen and energy metabolism in sepsis

Roland Dickerson, Robert C. Fried, Patricia M. Bailey, T. Peter Stein, James L. Mullen, Gordon P. Buzby

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Pharmacologic therapy designed to block adrenergic activity or alter hormonal milieu may modulate energy and protein metabolism in stress. The metabolic effects of propranolol (β adrenergic receptor blocker) in sepsis was investigated in 22 well-nourished rats that underwent superior vena caval cannulation, cecal ligation, and puncture. Animals were randomly assigned to receive either a continuous infusion of 0.7 mg/day of propranolol combined with parenteral nutrition (n = 11) or parenteral nutrition alone (n = 11). Both groups received isocaloric, isonitrogenous, isovolemic, parenteral nutrition post-operatively for 24 hr. Nitrogen balance was better for the propranolol group than for the control group (+743 ± 84 mg/kg/day versus +300 ± 63 mg/kg/day, respectively, P < 0.05). A significant difference between the pharmacologic therapy and control groups was noted for urinary 3-methylhistidine excretion versus control (0.99 ± 0.08 μg/kg/day versus 7.5 ± 0.37 μg/kg/day, respectively, P < 0.01). Measured energy expenditure was similar for both pharmacologic therapy and control groups (149 ± 20 kcal/kg/day versus 134 ± 11 kcal/kg/day, respectively, P = N.S.). No statistically significant difference was demonstrated for 24-hr survival between propranolol and control groups (73 and 64%, respectively). Continuous, low-dose propranolol promotes nitrogen retention and decreases 3-methylhistidine excretion without altering energy expenditure in parenterally fed septic rats.

Original languageEnglish (US)
Pages (from-to)38-41
Number of pages4
JournalJournal of Surgical Research
Volume48
Issue number1
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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Propranolol
Energy Metabolism
Sepsis
Nitrogen
Parenteral Nutrition
Control Groups
Venae Cavae
Adrenergic Antagonists
Punctures
Catheterization
Adrenergic Agents
Adrenergic Receptors
Ligation
Therapeutics
Proteins
3-methylhistidine

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Dickerson, R., Fried, R. C., Bailey, P. M., Stein, T. P., Mullen, J. L., & Buzby, G. P. (1990). Effect of propranolol on nitrogen and energy metabolism in sepsis. Journal of Surgical Research, 48(1), 38-41. https://doi.org/10.1016/0022-4804(90)90142-O

Effect of propranolol on nitrogen and energy metabolism in sepsis. / Dickerson, Roland; Fried, Robert C.; Bailey, Patricia M.; Stein, T. Peter; Mullen, James L.; Buzby, Gordon P.

In: Journal of Surgical Research, Vol. 48, No. 1, 01.01.1990, p. 38-41.

Research output: Contribution to journalArticle

Dickerson, Roland ; Fried, Robert C. ; Bailey, Patricia M. ; Stein, T. Peter ; Mullen, James L. ; Buzby, Gordon P. / Effect of propranolol on nitrogen and energy metabolism in sepsis. In: Journal of Surgical Research. 1990 ; Vol. 48, No. 1. pp. 38-41.
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