Effect of specific muscarinic M2 receptor antagonist on carbachol induced long-term REM sleep

Subimal Datta, J. J. Quattrochi, J. A. Hobson

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Six cats were chronically implanted with a standard set of sleep-scoring electrodes and bilateral stainless-steel guide tubes for microinjection of drugs in the peribrachial area (PBL). Pretreatment of drug injection sites in the PBL with the M2 antagonist methoctramine blocks both the immediate triggering of ponto-geniculo-occipital (PGO) waves and the later prolonged enhancement of REM sleep that is induced by carbachol. These results support the hypothesis that the carbachol effects are mediated via the M2 muscarinic receptor that is known to be present in the PBL.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalSleep
Volume16
Issue number1
StatePublished - 1993
Externally publishedYes

Fingerprint

Muscarinic M2 Receptors
REM Sleep
Carbachol
Stainless Steel
Microinjections
Pharmaceutical Preparations
Sleep
Electrodes
Cats
Injections
methoctramine

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

Effect of specific muscarinic M2 receptor antagonist on carbachol induced long-term REM sleep. / Datta, Subimal; Quattrochi, J. J.; Hobson, J. A.

In: Sleep, Vol. 16, No. 1, 1993, p. 8-14.

Research output: Contribution to journalArticle

Datta, Subimal ; Quattrochi, J. J. ; Hobson, J. A. / Effect of specific muscarinic M2 receptor antagonist on carbachol induced long-term REM sleep. In: Sleep. 1993 ; Vol. 16, No. 1. pp. 8-14.
@article{35ff9dcaf9044e64ab28a4a4cda9eace,
title = "Effect of specific muscarinic M2 receptor antagonist on carbachol induced long-term REM sleep",
abstract = "Six cats were chronically implanted with a standard set of sleep-scoring electrodes and bilateral stainless-steel guide tubes for microinjection of drugs in the peribrachial area (PBL). Pretreatment of drug injection sites in the PBL with the M2 antagonist methoctramine blocks both the immediate triggering of ponto-geniculo-occipital (PGO) waves and the later prolonged enhancement of REM sleep that is induced by carbachol. These results support the hypothesis that the carbachol effects are mediated via the M2 muscarinic receptor that is known to be present in the PBL.",
author = "Subimal Datta and Quattrochi, {J. J.} and Hobson, {J. A.}",
year = "1993",
language = "English (US)",
volume = "16",
pages = "8--14",
journal = "Sleep",
issn = "0161-8105",
publisher = "American Academy of Sleep Medicine",
number = "1",

}

TY - JOUR

T1 - Effect of specific muscarinic M2 receptor antagonist on carbachol induced long-term REM sleep

AU - Datta, Subimal

AU - Quattrochi, J. J.

AU - Hobson, J. A.

PY - 1993

Y1 - 1993

N2 - Six cats were chronically implanted with a standard set of sleep-scoring electrodes and bilateral stainless-steel guide tubes for microinjection of drugs in the peribrachial area (PBL). Pretreatment of drug injection sites in the PBL with the M2 antagonist methoctramine blocks both the immediate triggering of ponto-geniculo-occipital (PGO) waves and the later prolonged enhancement of REM sleep that is induced by carbachol. These results support the hypothesis that the carbachol effects are mediated via the M2 muscarinic receptor that is known to be present in the PBL.

AB - Six cats were chronically implanted with a standard set of sleep-scoring electrodes and bilateral stainless-steel guide tubes for microinjection of drugs in the peribrachial area (PBL). Pretreatment of drug injection sites in the PBL with the M2 antagonist methoctramine blocks both the immediate triggering of ponto-geniculo-occipital (PGO) waves and the later prolonged enhancement of REM sleep that is induced by carbachol. These results support the hypothesis that the carbachol effects are mediated via the M2 muscarinic receptor that is known to be present in the PBL.

UR - http://www.scopus.com/inward/record.url?scp=0027444294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027444294&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 8

EP - 14

JO - Sleep

JF - Sleep

SN - 0161-8105

IS - 1

ER -