Effect of sustained endotoxemia on α1-adrenergic responsiveness in parenterally fed rats

Roland Dickerson, John J. Lima, David A. Kuhl, Rex O. Brown, Lawrence J. Hak

Research output: Contribution to journalArticle

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Abstract

We investigated the effect of endotoxemia on α1-adrenergic receptor- mediated smooth muscle contraction as measured by mean arterial pressure (MAP) in response to incrementaL doses of a vasopressor. Twelve male Sprague- Dawley rats were randomized to receive parenteral nutrition alone (PN) or in combination with a continuous infusion of endotoxin (PN-LPS) for 48 hours. Incremental doses of phenylephrine were given and peak MAP response was recorded. The endotoxin group had a decreased rise in MAP with the same dose of phenylephrine compared with the control group (59 ± 14 and 99 ± 12 mm Hg, respectively, p<0.001). However, the baseline MAP was higher in the endotoxin group (102 ± 18 and 71 ± 7 mm Hg, respectively, p<0.002). The overall maximum effect was the same for both groups (161 ± 16 and 170 ± 8 mm Hg, respectively, p=NS). These data indicate that sustained endotoxemia does not result in desensitization of α1-adrenergic responsiveness. Other mechanisms are responsible for the ineffectiveness of vasopressors during advanced sepsis.

Original languageEnglish (US)
Pages (from-to)170-174
Number of pages5
JournalPharmacotherapy
Volume18
Issue number1
StatePublished - Jan 1998

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Endotoxemia
Adrenergic Agents
Arterial Pressure
Endotoxins
Parenteral Nutrition
Phenylephrine
Muscle Contraction
Adrenergic Receptors
Smooth Muscle
Sprague Dawley Rats
Sepsis
Control Groups

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Dickerson, R., Lima, J. J., Kuhl, D. A., Brown, R. O., & Hak, L. J. (1998). Effect of sustained endotoxemia on α1-adrenergic responsiveness in parenterally fed rats. Pharmacotherapy, 18(1), 170-174.

Effect of sustained endotoxemia on α1-adrenergic responsiveness in parenterally fed rats. / Dickerson, Roland; Lima, John J.; Kuhl, David A.; Brown, Rex O.; Hak, Lawrence J.

In: Pharmacotherapy, Vol. 18, No. 1, 01.1998, p. 170-174.

Research output: Contribution to journalArticle

Dickerson, R, Lima, JJ, Kuhl, DA, Brown, RO & Hak, LJ 1998, 'Effect of sustained endotoxemia on α1-adrenergic responsiveness in parenterally fed rats', Pharmacotherapy, vol. 18, no. 1, pp. 170-174.
Dickerson, Roland ; Lima, John J. ; Kuhl, David A. ; Brown, Rex O. ; Hak, Lawrence J. / Effect of sustained endotoxemia on α1-adrenergic responsiveness in parenterally fed rats. In: Pharmacotherapy. 1998 ; Vol. 18, No. 1. pp. 170-174.
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