Effect of synthetic estrogen on platelet aggregation and vascular release of PGI2-like material in the rabbit

Marshall Elam, G. E. Limscomb, C. M. Chesney, D. A. Terragno, N. A. Terragno

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Treatment of adult female New Zealand white rabbits with ethinyl estradiol, the synthetic estrogen used in many oral contraceptives, results in a significant increase in in vivo aggregation. This alteration in platelet behavior is accompanied by diminished vascular release of antiaggregatory PGI2 (prostacyclin)-like material. Addition of a progestin prevents the change in platelet aggregation seen with the estrogen alone. Diminished vascular PGI2 release may be an important factor in the pathogenesis of thrombotic occurrences experienced by some oral contraceptive users. In vivo platelet aggregation may be of value in identifying individuals at risk of developing thrombotic disturbances while taking oral contraceptives.

Original languageEnglish (US)
Pages (from-to)1039-1051
Number of pages13
JournalProstaglandins
Volume20
Issue number6
DOIs
StatePublished - Jan 1 1980

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Estradiol Congeners
Epoprostenol
Oral Contraceptives
Platelets
Platelet Aggregation
Blood Vessels
Agglomeration
Rabbits
Ethinyl Estradiol
Progestins
Estrogens
Blood Platelets

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology

Cite this

Effect of synthetic estrogen on platelet aggregation and vascular release of PGI2-like material in the rabbit. / Elam, Marshall; Limscomb, G. E.; Chesney, C. M.; Terragno, D. A.; Terragno, N. A.

In: Prostaglandins, Vol. 20, No. 6, 01.01.1980, p. 1039-1051.

Research output: Contribution to journalArticle

Elam, Marshall ; Limscomb, G. E. ; Chesney, C. M. ; Terragno, D. A. ; Terragno, N. A. / Effect of synthetic estrogen on platelet aggregation and vascular release of PGI2-like material in the rabbit. In: Prostaglandins. 1980 ; Vol. 20, No. 6. pp. 1039-1051.
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