Effect of taurine on human fetal neuron cells

Proliferation and differentiation

Xue Cun Chen, Zhi Ling Pan, Dong Sheng Liu, Xiaobin Han

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The purpose of this study was to investigate the effect of taurine on human fetal brain neuron cell proliferation and differentiation using a glial-free, pure cerebral neuronal culture grown in a serum-free environment. We found that taurine was necessary for neuronal survival and neurite extension. Taurine, on the other hand, has a trophic effect on the human fetal brain cell, promoting both proliferation and differentiation. Results showed that DNA synthesis of the neurons was increased in a dose-dependent manner when neurons were cultured in the medium containing taurine (100-6400 μM). The protein content of neuronal cells was also significantly increased in the neurons treated with taurine was compared to the control. At day 15, the expression of neuron-specific enolase (NSE) was only detected in the neurons cultured in the medium containing taurine. These results establish taurine as a putative human fetal brain neurontrophic factor in the process of human brain development.

Original languageEnglish (US)
Pages (from-to)397-403
Number of pages7
JournalAdvances in Experimental Medicine and Biology
Volume442
StatePublished - Jul 18 1998

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Taurine
Cell proliferation
Neurons
Cell Differentiation
Cell Proliferation
Brain
Phosphopyruvate Hydratase
Human Development
Neurites
Neuroglia
DNA
Serum
Proteins

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Effect of taurine on human fetal neuron cells : Proliferation and differentiation. / Chen, Xue Cun; Pan, Zhi Ling; Liu, Dong Sheng; Han, Xiaobin.

In: Advances in Experimental Medicine and Biology, Vol. 442, 18.07.1998, p. 397-403.

Research output: Contribution to journalArticle

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