Effect of the inhibition of dopamine uptake on the dopamine- and dimethyldopamine-induced-inhibition of the potassium-evoked release of [3H] acetylcholine from striatal slices

T. Farooqui, R. A. Wallace, Duane Miller, N. J. Uretsky

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

1. Dimethyldopamine was eight times more potent than dopamine in activating the D2 receptor that inhibits the potassium-evoked release of [3H]acetylcholine from striatal slices. 2. Cocaine and mazindol produced an eight-fold shift in the concentration-response curve for dopamine, but not for dimethyldopamine. 3. The IC50 of dimethyldopamine for the inhibition of [3H]dopamine uptake was thirty times greater than that for dopamine. 4. Dopamine may be less potent than dimethyldopamine at the D2 receptor because dopamine has a higher affinity for the dopamine uptake system, resulting in its rapid removal from the vicinity of the receptor.

Original languageEnglish (US)
Pages (from-to)731-736
Number of pages6
JournalGeneral Pharmacology
Volume20
Issue number6
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Corpus Striatum
Acetylcholine
Dopamine
Potassium
Mazindol
Dopamine D2 Receptors
Cocaine
Inhibitory Concentration 50

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Effect of the inhibition of dopamine uptake on the dopamine- and dimethyldopamine-induced-inhibition of the potassium-evoked release of [3H] acetylcholine from striatal slices. / Farooqui, T.; Wallace, R. A.; Miller, Duane; Uretsky, N. J.

In: General Pharmacology, Vol. 20, No. 6, 01.01.1989, p. 731-736.

Research output: Contribution to journalArticle

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