Effect of total parenteral nutrition with xylitol on protein and energy metabolism in thermally injured rats

Michael Karlstad, S. J. DeMichele, B. R. Bistrain, G. L. Blackburn

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3 Citations (Scopus)

Abstract

The use of xylitol as an alternative carbohydrate calorie source in total parenteral nutrition may offer unique pharmacologic and nutritional properties in the therapy of the thermally injured. Male Sprague-Dawley rats (250 g) received a 15-second dorsal scald injury (25-30% BSA) and were parenterally fed isovolemic diets (60 ml/day) that provided 200 kcal/kg/d, 9.68 g of amino acids/kg/d, and 23.5% nonprotein calories (NPC) as fat for 3 days. The balance of NPC were provided as dextrose (Dex) or 50% xylitol:50% dextrose (Xyl/Dex). Rectus muscle and liver fractional protein synthetic rates (FSR, %/day), whole body leucine appearance (Flux), oxidation (OX), protein breakdown (PB), and synthesis (PS) were estimated using a 4-hour iv infusion of [1-14C]leucine on day 3. Mean values (±SE) for leucine kinetics (μmol leucine/hr/100 g), cumulative nitrogen balance (mg N) and plasma insulin concentration (Table I). (μU/mL). The partial replacement of dextrose calories with xylitol did not significantly alter whole body and tissue leucine kinetics, daily and cumulative nitrogen balance, insulin concentration, and energy expenditure (indirect calorimetry). These data indicate that xylitol may be useful as an alternative carbohydrate calorie source in parenteral nutrition to avoid possible deleterious side effects of glucose overfeeding in the critically ill but did not improve protein metabolism under the conditions of this study.

Original languageEnglish (US)
Pages (from-to)445-449
Number of pages5
JournalJournal of Parenteral and Enteral Nutrition
Volume15
Issue number4
DOIs
StatePublished - Jan 1 1991

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Xylitol
Total Parenteral Nutrition
Leucine
Energy Metabolism
Glucose
Proteins
Nitrogen
Carbohydrates
Insulin
Indirect Calorimetry
Parenteral Nutrition
Critical Illness
Sprague Dawley Rats
Fats
Diet
Amino Acids
Muscles
Liver
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effect of total parenteral nutrition with xylitol on protein and energy metabolism in thermally injured rats. / Karlstad, Michael; DeMichele, S. J.; Bistrain, B. R.; Blackburn, G. L.

In: Journal of Parenteral and Enteral Nutrition, Vol. 15, No. 4, 01.01.1991, p. 445-449.

Research output: Contribution to journalArticle

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