Effect on survival of estrogen replacement therapy after coronary artery bypass grafting

Jay M. Sullivan, Faten El-Zeky, Roger Vander Zwaag, K Ramanathan

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

We examined the relation between postmenopausal estrogen placement therapy (ERT) and survival in 1,098 women who underwent coronary artery bypass grafting (CABG). Patients wore selected for the study if their age was ≤55 years at the time of preoperative coronary angiography or if they had previously undergone bilateral oophorectomy. Life-table analysis was used to compare survival after surgery in 92 women who received ERT and 1,006 women who did not. Five-year survival was 98.8% in the estrogen users and 82.3% in the non-users. Ten-year survival was 81.4% in the users and 65.1% in the nonusers (p = 0.0001 by Lee Desu test). The women who did not take estrogen were significantly older (p <0.001), had more vessels with significant stenosis (p = 0.033), lower ejection fractions (p = 0.051), and more prior myocardial infarctions (p = 0.054). However, a Cox proportional-hazards model selected the number of coronary arteries narrowed (RR 1.43, p <0.0001), estrogen use (RR 0.38, p = 0.001), left main coronary stenosis (RR 1.83, p = 0.001), and diabetes mellitus (RR 1.57, p = 0.003) as the significant independent predictors of survival. These data suggest that ERT improves survival significantly after CABG in postmenopausal women with coronary artery disease.

Original languageEnglish (US)
Pages (from-to)847-850
Number of pages4
JournalAmerican Journal of Cardiology
Volume79
Issue number7
DOIs
StatePublished - Apr 1 1997

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Estrogen Replacement Therapy
Coronary Artery Bypass
Estrogens
Survival
Life Tables
Coronary Stenosis
Ovariectomy
Coronary Angiography
Proportional Hazards Models
Coronary Artery Disease
Coronary Vessels
Diabetes Mellitus
Pathologic Constriction
Therapeutics
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Effect on survival of estrogen replacement therapy after coronary artery bypass grafting. / Sullivan, Jay M.; El-Zeky, Faten; Zwaag, Roger Vander; Ramanathan, K.

In: American Journal of Cardiology, Vol. 79, No. 7, 01.04.1997, p. 847-850.

Research output: Contribution to journalArticle

Sullivan, Jay M. ; El-Zeky, Faten ; Zwaag, Roger Vander ; Ramanathan, K. / Effect on survival of estrogen replacement therapy after coronary artery bypass grafting. In: American Journal of Cardiology. 1997 ; Vol. 79, No. 7. pp. 847-850.
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