Effects of age, gender, and myostatin genotype on the hypertrophic response to heavy resistance strength training

Frederick M. Ivey, Ben F. Hurley, Stephen M. Roth, Robert E. Ferrell, Brian L. Tracy, Jeffrey T. Lemmer, Diane E. Hurlbut, Gregory F. Martel, Eliot L. Siegel, James L. Fozard, E. Metter, Jerome L. Fleg

Research output: Contribution to journalArticle

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Abstract

Background. Because of the scarcity of data available from direct comparisons of age and gender groups using the same relative training stimulus, it is unknown whether older individuals can increase their muscle mass as much as young individuals and whether women can increase as much as men in response to strength training (ST). In addition, little is known about whether the hypertrophic response to ST is affected by myostatin genotype, a candidate gene for muscle hypertrophy. Methods. Eleven young men (25 ± 3 years, range 21-29 years), 11 young women (26 ± 2 years, range 23-28 years), 12 older men (69 ± 3 years, range 65-75 years), and 11 older women (68 ± 2 years, range 65-73 years) had bilateral quadriceps muscle volume measurements performed using magnetic resonance imaging (MRI) before and after ST and detraining. Training consisted of knee extension exercises of the dominant leg three times per week for 9 weeks. The contralateral limb was left untrained throughout the ST program. Following the unilateral training period, the subjects underwent 31 weeks of detraining during which no regular exercise was performed. Myostatin genotype was determined in a subgroup of 32 subjects, of which five female subjects were carders of a myostatin gene variant. Results. A significantly greater absolute increase in muscle volume was observed in men than in women (204 ± 20 vs 101 ± 13 cm3, p < .01), but there was no significant difference in muscle volume response to ST between young and older individuals. The gender effect remained after adjusting for baseline muscle volume. In addition, there was a significantly greater loss of absolute muscle volume after 31 weeks of detraining in men than in women (151 ± 13 vs 88 ± 7 cm3, p < .05), but no significant difference between young and older individuals. Myostatin genotype did not explain the hypertrophic response to ST when all 32 subjects were assessed. However, when only women were analyzed, those with the less common myostatin allele exhibited a 68% larger increase in muscle volume in response to ST (p = .056). Conclusions. Aging does not affect the muscle mass response to either ST or detraining, whereas gender does, as men increased their muscle volume about twice as much in response to ST as did women and experienced larger losses in response to detraining than women. Young men were the only group that maintained muscle volume adaptation after 31 weeks of detraining. Although myostatin genotype may not explain the observed gender difference in the hypertrophic response to ST, a role for myostatin genotype may be indicated in this regard for women, but future studies are needed with larger subject numbers in each genotype group to confirm this observation.

Original languageEnglish (US)
Pages (from-to)M641-M648
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume55
Issue number11
DOIs
StatePublished - Jan 1 2000

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Myostatin
Resistance Training
Genotype
Muscles
Exercise
Quadriceps Muscle
Hypertrophy
Genes
Leg
Knee
Extremities
Age Groups
Alleles
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

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Effects of age, gender, and myostatin genotype on the hypertrophic response to heavy resistance strength training. / Ivey, Frederick M.; Hurley, Ben F.; Roth, Stephen M.; Ferrell, Robert E.; Tracy, Brian L.; Lemmer, Jeffrey T.; Hurlbut, Diane E.; Martel, Gregory F.; Siegel, Eliot L.; Fozard, James L.; Metter, E.; Fleg, Jerome L.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 55, No. 11, 01.01.2000, p. M641-M648.

Research output: Contribution to journalArticle

Ivey, FM, Hurley, BF, Roth, SM, Ferrell, RE, Tracy, BL, Lemmer, JT, Hurlbut, DE, Martel, GF, Siegel, EL, Fozard, JL, Metter, E & Fleg, JL 2000, 'Effects of age, gender, and myostatin genotype on the hypertrophic response to heavy resistance strength training', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 55, no. 11, pp. M641-M648. https://doi.org/10.1093/gerona/55.11.M641
Ivey, Frederick M. ; Hurley, Ben F. ; Roth, Stephen M. ; Ferrell, Robert E. ; Tracy, Brian L. ; Lemmer, Jeffrey T. ; Hurlbut, Diane E. ; Martel, Gregory F. ; Siegel, Eliot L. ; Fozard, James L. ; Metter, E. ; Fleg, Jerome L. / Effects of age, gender, and myostatin genotype on the hypertrophic response to heavy resistance strength training. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2000 ; Vol. 55, No. 11. pp. M641-M648.
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abstract = "Background. Because of the scarcity of data available from direct comparisons of age and gender groups using the same relative training stimulus, it is unknown whether older individuals can increase their muscle mass as much as young individuals and whether women can increase as much as men in response to strength training (ST). In addition, little is known about whether the hypertrophic response to ST is affected by myostatin genotype, a candidate gene for muscle hypertrophy. Methods. Eleven young men (25 ± 3 years, range 21-29 years), 11 young women (26 ± 2 years, range 23-28 years), 12 older men (69 ± 3 years, range 65-75 years), and 11 older women (68 ± 2 years, range 65-73 years) had bilateral quadriceps muscle volume measurements performed using magnetic resonance imaging (MRI) before and after ST and detraining. Training consisted of knee extension exercises of the dominant leg three times per week for 9 weeks. The contralateral limb was left untrained throughout the ST program. Following the unilateral training period, the subjects underwent 31 weeks of detraining during which no regular exercise was performed. Myostatin genotype was determined in a subgroup of 32 subjects, of which five female subjects were carders of a myostatin gene variant. Results. A significantly greater absolute increase in muscle volume was observed in men than in women (204 ± 20 vs 101 ± 13 cm3, p < .01), but there was no significant difference in muscle volume response to ST between young and older individuals. The gender effect remained after adjusting for baseline muscle volume. In addition, there was a significantly greater loss of absolute muscle volume after 31 weeks of detraining in men than in women (151 ± 13 vs 88 ± 7 cm3, p < .05), but no significant difference between young and older individuals. Myostatin genotype did not explain the hypertrophic response to ST when all 32 subjects were assessed. However, when only women were analyzed, those with the less common myostatin allele exhibited a 68{\%} larger increase in muscle volume in response to ST (p = .056). Conclusions. Aging does not affect the muscle mass response to either ST or detraining, whereas gender does, as men increased their muscle volume about twice as much in response to ST as did women and experienced larger losses in response to detraining than women. Young men were the only group that maintained muscle volume adaptation after 31 weeks of detraining. Although myostatin genotype may not explain the observed gender difference in the hypertrophic response to ST, a role for myostatin genotype may be indicated in this regard for women, but future studies are needed with larger subject numbers in each genotype group to confirm this observation.",
author = "Ivey, {Frederick M.} and Hurley, {Ben F.} and Roth, {Stephen M.} and Ferrell, {Robert E.} and Tracy, {Brian L.} and Lemmer, {Jeffrey T.} and Hurlbut, {Diane E.} and Martel, {Gregory F.} and Siegel, {Eliot L.} and Fozard, {James L.} and E. Metter and Fleg, {Jerome L.}",
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TY - JOUR

T1 - Effects of age, gender, and myostatin genotype on the hypertrophic response to heavy resistance strength training

AU - Ivey, Frederick M.

AU - Hurley, Ben F.

AU - Roth, Stephen M.

AU - Ferrell, Robert E.

AU - Tracy, Brian L.

AU - Lemmer, Jeffrey T.

AU - Hurlbut, Diane E.

AU - Martel, Gregory F.

AU - Siegel, Eliot L.

AU - Fozard, James L.

AU - Metter, E.

AU - Fleg, Jerome L.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Background. Because of the scarcity of data available from direct comparisons of age and gender groups using the same relative training stimulus, it is unknown whether older individuals can increase their muscle mass as much as young individuals and whether women can increase as much as men in response to strength training (ST). In addition, little is known about whether the hypertrophic response to ST is affected by myostatin genotype, a candidate gene for muscle hypertrophy. Methods. Eleven young men (25 ± 3 years, range 21-29 years), 11 young women (26 ± 2 years, range 23-28 years), 12 older men (69 ± 3 years, range 65-75 years), and 11 older women (68 ± 2 years, range 65-73 years) had bilateral quadriceps muscle volume measurements performed using magnetic resonance imaging (MRI) before and after ST and detraining. Training consisted of knee extension exercises of the dominant leg three times per week for 9 weeks. The contralateral limb was left untrained throughout the ST program. Following the unilateral training period, the subjects underwent 31 weeks of detraining during which no regular exercise was performed. Myostatin genotype was determined in a subgroup of 32 subjects, of which five female subjects were carders of a myostatin gene variant. Results. A significantly greater absolute increase in muscle volume was observed in men than in women (204 ± 20 vs 101 ± 13 cm3, p < .01), but there was no significant difference in muscle volume response to ST between young and older individuals. The gender effect remained after adjusting for baseline muscle volume. In addition, there was a significantly greater loss of absolute muscle volume after 31 weeks of detraining in men than in women (151 ± 13 vs 88 ± 7 cm3, p < .05), but no significant difference between young and older individuals. Myostatin genotype did not explain the hypertrophic response to ST when all 32 subjects were assessed. However, when only women were analyzed, those with the less common myostatin allele exhibited a 68% larger increase in muscle volume in response to ST (p = .056). Conclusions. Aging does not affect the muscle mass response to either ST or detraining, whereas gender does, as men increased their muscle volume about twice as much in response to ST as did women and experienced larger losses in response to detraining than women. Young men were the only group that maintained muscle volume adaptation after 31 weeks of detraining. Although myostatin genotype may not explain the observed gender difference in the hypertrophic response to ST, a role for myostatin genotype may be indicated in this regard for women, but future studies are needed with larger subject numbers in each genotype group to confirm this observation.

AB - Background. Because of the scarcity of data available from direct comparisons of age and gender groups using the same relative training stimulus, it is unknown whether older individuals can increase their muscle mass as much as young individuals and whether women can increase as much as men in response to strength training (ST). In addition, little is known about whether the hypertrophic response to ST is affected by myostatin genotype, a candidate gene for muscle hypertrophy. Methods. Eleven young men (25 ± 3 years, range 21-29 years), 11 young women (26 ± 2 years, range 23-28 years), 12 older men (69 ± 3 years, range 65-75 years), and 11 older women (68 ± 2 years, range 65-73 years) had bilateral quadriceps muscle volume measurements performed using magnetic resonance imaging (MRI) before and after ST and detraining. Training consisted of knee extension exercises of the dominant leg three times per week for 9 weeks. The contralateral limb was left untrained throughout the ST program. Following the unilateral training period, the subjects underwent 31 weeks of detraining during which no regular exercise was performed. Myostatin genotype was determined in a subgroup of 32 subjects, of which five female subjects were carders of a myostatin gene variant. Results. A significantly greater absolute increase in muscle volume was observed in men than in women (204 ± 20 vs 101 ± 13 cm3, p < .01), but there was no significant difference in muscle volume response to ST between young and older individuals. The gender effect remained after adjusting for baseline muscle volume. In addition, there was a significantly greater loss of absolute muscle volume after 31 weeks of detraining in men than in women (151 ± 13 vs 88 ± 7 cm3, p < .05), but no significant difference between young and older individuals. Myostatin genotype did not explain the hypertrophic response to ST when all 32 subjects were assessed. However, when only women were analyzed, those with the less common myostatin allele exhibited a 68% larger increase in muscle volume in response to ST (p = .056). Conclusions. Aging does not affect the muscle mass response to either ST or detraining, whereas gender does, as men increased their muscle volume about twice as much in response to ST as did women and experienced larger losses in response to detraining than women. Young men were the only group that maintained muscle volume adaptation after 31 weeks of detraining. Although myostatin genotype may not explain the observed gender difference in the hypertrophic response to ST, a role for myostatin genotype may be indicated in this regard for women, but future studies are needed with larger subject numbers in each genotype group to confirm this observation.

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