Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: A 2-y randomized trial

Sulin Cheng, Arja Lyytikäinen, Heikki Kröger, Christel Lamberg-Allardt, Markku Alén, Arvo Koistinen, Qing Ju Wang, Miia Suuriniemi, Harri Suominen, Anitta Mahonen, Patrick H.F. Nicholson, Kaisa K. Ivaska, Riitta Korpela, Claes Ohlsson, Kalervo H. Väänänen, Frances Tylavsky

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Background: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone mass accrual during the rapid growth period. Objective: The purpose was to examine the effects of both food-based and pill supplements of calcium and vitamin D on bone mass and body composition in girls aged 10-12 y. Design: This placebo-controlled intervention trial randomly assigned 195 healthy girls at Tanner stage I-II, aged 10-12 y, with dietary calcium intakes <900 mg/d to 1 of 4 groups: calcium (1000 mg) + vitamin D3 (200 IU), calcium (1000 mg), cheese (1000 mg calcium), and placebo. Primary outcomes were bone indexes of the hip, spine, and whole body by dual-energy X-ray absorptiometry and of the radius and tibia by peripheral quantitative computed tomography. Results: With the use of intention-to-treat or efficacy analysis, calcium supplementation with cheese resulted in a higher percentage change in cortical thickness of the tibia than did placebo, calcium, or calcium + vitamin D treatment (P = 0.01, 0.038, and 0.004, respectively) and in higher whole-body bone mineral density than did placebo treatment (P = 0.044) when compliance was >50%. With the use of a hierarchical linear model with random effects to control for growth velocity, these differences disappeared. Conclusions: Increasing calcium intake by consuming cheese appears to be more beneficial for cortical bone mass accrual than the consumption of tablets containing a similar amount of calcium. Diverse patterns of growth velocity may mask the efficacy of supplementation in a short-term trial of children transiting through puberty.

Original languageEnglish (US)
Pages (from-to)1115-1126
Number of pages12
JournalAmerican Journal of Clinical Nutrition
Volume82
Issue number5
StatePublished - Dec 1 2005

Fingerprint

Dairy Products
Body Composition
varespladib methyl
Vitamin D
Calcium
Bone and Bones
Growth
Dietary Calcium
Cheese
Puberty
Masks
Dietary Supplements
Tablets
Linear Models
Placebos
Food

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls : A 2-y randomized trial. / Cheng, Sulin; Lyytikäinen, Arja; Kröger, Heikki; Lamberg-Allardt, Christel; Alén, Markku; Koistinen, Arvo; Wang, Qing Ju; Suuriniemi, Miia; Suominen, Harri; Mahonen, Anitta; Nicholson, Patrick H.F.; Ivaska, Kaisa K.; Korpela, Riitta; Ohlsson, Claes; Väänänen, Kalervo H.; Tylavsky, Frances.

In: American Journal of Clinical Nutrition, Vol. 82, No. 5, 01.12.2005, p. 1115-1126.

Research output: Contribution to journalArticle

Cheng, S, Lyytikäinen, A, Kröger, H, Lamberg-Allardt, C, Alén, M, Koistinen, A, Wang, QJ, Suuriniemi, M, Suominen, H, Mahonen, A, Nicholson, PHF, Ivaska, KK, Korpela, R, Ohlsson, C, Väänänen, KH & Tylavsky, F 2005, 'Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: A 2-y randomized trial', American Journal of Clinical Nutrition, vol. 82, no. 5, pp. 1115-1126.
Cheng, Sulin ; Lyytikäinen, Arja ; Kröger, Heikki ; Lamberg-Allardt, Christel ; Alén, Markku ; Koistinen, Arvo ; Wang, Qing Ju ; Suuriniemi, Miia ; Suominen, Harri ; Mahonen, Anitta ; Nicholson, Patrick H.F. ; Ivaska, Kaisa K. ; Korpela, Riitta ; Ohlsson, Claes ; Väänänen, Kalervo H. ; Tylavsky, Frances. / Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls : A 2-y randomized trial. In: American Journal of Clinical Nutrition. 2005 ; Vol. 82, No. 5. pp. 1115-1126.
@article{f74bdfe64d4e498bbcee1458bb2a7e6a,
title = "Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: A 2-y randomized trial",
abstract = "Background: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone mass accrual during the rapid growth period. Objective: The purpose was to examine the effects of both food-based and pill supplements of calcium and vitamin D on bone mass and body composition in girls aged 10-12 y. Design: This placebo-controlled intervention trial randomly assigned 195 healthy girls at Tanner stage I-II, aged 10-12 y, with dietary calcium intakes <900 mg/d to 1 of 4 groups: calcium (1000 mg) + vitamin D3 (200 IU), calcium (1000 mg), cheese (1000 mg calcium), and placebo. Primary outcomes were bone indexes of the hip, spine, and whole body by dual-energy X-ray absorptiometry and of the radius and tibia by peripheral quantitative computed tomography. Results: With the use of intention-to-treat or efficacy analysis, calcium supplementation with cheese resulted in a higher percentage change in cortical thickness of the tibia than did placebo, calcium, or calcium + vitamin D treatment (P = 0.01, 0.038, and 0.004, respectively) and in higher whole-body bone mineral density than did placebo treatment (P = 0.044) when compliance was >50{\%}. With the use of a hierarchical linear model with random effects to control for growth velocity, these differences disappeared. Conclusions: Increasing calcium intake by consuming cheese appears to be more beneficial for cortical bone mass accrual than the consumption of tablets containing a similar amount of calcium. Diverse patterns of growth velocity may mask the efficacy of supplementation in a short-term trial of children transiting through puberty.",
author = "Sulin Cheng and Arja Lyytik{\"a}inen and Heikki Kr{\"o}ger and Christel Lamberg-Allardt and Markku Al{\'e}n and Arvo Koistinen and Wang, {Qing Ju} and Miia Suuriniemi and Harri Suominen and Anitta Mahonen and Nicholson, {Patrick H.F.} and Ivaska, {Kaisa K.} and Riitta Korpela and Claes Ohlsson and V{\"a}{\"a}n{\"a}nen, {Kalervo H.} and Frances Tylavsky",
year = "2005",
month = "12",
day = "1",
language = "English (US)",
volume = "82",
pages = "1115--1126",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "5",

}

TY - JOUR

T1 - Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls

T2 - A 2-y randomized trial

AU - Cheng, Sulin

AU - Lyytikäinen, Arja

AU - Kröger, Heikki

AU - Lamberg-Allardt, Christel

AU - Alén, Markku

AU - Koistinen, Arvo

AU - Wang, Qing Ju

AU - Suuriniemi, Miia

AU - Suominen, Harri

AU - Mahonen, Anitta

AU - Nicholson, Patrick H.F.

AU - Ivaska, Kaisa K.

AU - Korpela, Riitta

AU - Ohlsson, Claes

AU - Väänänen, Kalervo H.

AU - Tylavsky, Frances

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Background: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone mass accrual during the rapid growth period. Objective: The purpose was to examine the effects of both food-based and pill supplements of calcium and vitamin D on bone mass and body composition in girls aged 10-12 y. Design: This placebo-controlled intervention trial randomly assigned 195 healthy girls at Tanner stage I-II, aged 10-12 y, with dietary calcium intakes <900 mg/d to 1 of 4 groups: calcium (1000 mg) + vitamin D3 (200 IU), calcium (1000 mg), cheese (1000 mg calcium), and placebo. Primary outcomes were bone indexes of the hip, spine, and whole body by dual-energy X-ray absorptiometry and of the radius and tibia by peripheral quantitative computed tomography. Results: With the use of intention-to-treat or efficacy analysis, calcium supplementation with cheese resulted in a higher percentage change in cortical thickness of the tibia than did placebo, calcium, or calcium + vitamin D treatment (P = 0.01, 0.038, and 0.004, respectively) and in higher whole-body bone mineral density than did placebo treatment (P = 0.044) when compliance was >50%. With the use of a hierarchical linear model with random effects to control for growth velocity, these differences disappeared. Conclusions: Increasing calcium intake by consuming cheese appears to be more beneficial for cortical bone mass accrual than the consumption of tablets containing a similar amount of calcium. Diverse patterns of growth velocity may mask the efficacy of supplementation in a short-term trial of children transiting through puberty.

AB - Background: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone mass accrual during the rapid growth period. Objective: The purpose was to examine the effects of both food-based and pill supplements of calcium and vitamin D on bone mass and body composition in girls aged 10-12 y. Design: This placebo-controlled intervention trial randomly assigned 195 healthy girls at Tanner stage I-II, aged 10-12 y, with dietary calcium intakes <900 mg/d to 1 of 4 groups: calcium (1000 mg) + vitamin D3 (200 IU), calcium (1000 mg), cheese (1000 mg calcium), and placebo. Primary outcomes were bone indexes of the hip, spine, and whole body by dual-energy X-ray absorptiometry and of the radius and tibia by peripheral quantitative computed tomography. Results: With the use of intention-to-treat or efficacy analysis, calcium supplementation with cheese resulted in a higher percentage change in cortical thickness of the tibia than did placebo, calcium, or calcium + vitamin D treatment (P = 0.01, 0.038, and 0.004, respectively) and in higher whole-body bone mineral density than did placebo treatment (P = 0.044) when compliance was >50%. With the use of a hierarchical linear model with random effects to control for growth velocity, these differences disappeared. Conclusions: Increasing calcium intake by consuming cheese appears to be more beneficial for cortical bone mass accrual than the consumption of tablets containing a similar amount of calcium. Diverse patterns of growth velocity may mask the efficacy of supplementation in a short-term trial of children transiting through puberty.

UR - http://www.scopus.com/inward/record.url?scp=32944478966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32944478966&partnerID=8YFLogxK

M3 - Article

C2 - 16280447

AN - SCOPUS:32944478966

VL - 82

SP - 1115

EP - 1126

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -