Effects of cholesterol loading of mouse macrophages on carnitine palmitoyltransferase activity and sensitivity to inhibition by malonyl-CoA

Khosrow Kashfi, Ladislav Dory, George Cook

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Scavenger receptor-mediated uptake of acetylated low density lipoprotein-derived cholesterol by peritoneal mouse macrophages resulted in decreased activity of the malonyl-CoA inhibitable carnitine palmitoyltransferase and a decrease in the sensitivity of this enzyme to inhibition by malonyl-CoA.

Original languageEnglish (US)
Pages (from-to)1121-1126
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume177
Issue number3
DOIs
StatePublished - Jun 28 1991

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Malonyl Coenzyme A
Carnitine O-Palmitoyltransferase
Macrophages
Cholesterol
Scavenger Receptors
Peritoneal Macrophages
LDL Cholesterol
Enzymes
acetyl-LDL

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

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title = "Effects of cholesterol loading of mouse macrophages on carnitine palmitoyltransferase activity and sensitivity to inhibition by malonyl-CoA",
abstract = "Scavenger receptor-mediated uptake of acetylated low density lipoprotein-derived cholesterol by peritoneal mouse macrophages resulted in decreased activity of the malonyl-CoA inhibitable carnitine palmitoyltransferase and a decrease in the sensitivity of this enzyme to inhibition by malonyl-CoA.",
author = "Khosrow Kashfi and Ladislav Dory and George Cook",
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