Effects of colorectal cancer risk factors on the association between aspirin and colorectal cancer

Max E. Seaton, Ulrike Peters, Karen Johnson, Charles Kooperberg, Andrea Bafford, Niha Zubair

Research output: Contribution to journalArticle

Abstract

Background/Aim: We investigated the effect of aspirin on colorectal cancer (CRC) risk among subgroups of women with and without risk factors for CRC. Patients and Methods: Using data from the Women’s Health Initiative, we estimated hazard ratios for CRC in association with aspirin use, with stratifications by cardiovascular disease (CVD) risk status, family history of CRC, and history of colorectal polypectomy. Results: Aspirin was associated with a lower risk of CRC among women with low/normal or high CVD-risk status; no family history of CRC; or a history of colonoscopy with polypectomy. Aspirin was not associated with CRC among women with a family history of CRC or a history of colonoscopy without polypectomy. Conclusion: Aspirin was associated with a lower risk of CRC in women at all levels of CVD-risk, in those with a history of colonoscopy with polypectomy, and in those without a family history of CRC.

Original languageEnglish (US)
Pages (from-to)4877-4884
Number of pages8
JournalAnticancer research
Volume39
Issue number9
DOIs
StatePublished - Jan 1 2019

Fingerprint

Aspirin
Colorectal Neoplasms
Colonoscopy
Cardiovascular Diseases
Women's Health

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Effects of colorectal cancer risk factors on the association between aspirin and colorectal cancer. / Seaton, Max E.; Peters, Ulrike; Johnson, Karen; Kooperberg, Charles; Bafford, Andrea; Zubair, Niha.

In: Anticancer research, Vol. 39, No. 9, 01.01.2019, p. 4877-4884.

Research output: Contribution to journalArticle

Seaton, Max E. ; Peters, Ulrike ; Johnson, Karen ; Kooperberg, Charles ; Bafford, Andrea ; Zubair, Niha. / Effects of colorectal cancer risk factors on the association between aspirin and colorectal cancer. In: Anticancer research. 2019 ; Vol. 39, No. 9. pp. 4877-4884.
@article{39b3ffb3309c4cdab492f8ad04c0e1e4,
title = "Effects of colorectal cancer risk factors on the association between aspirin and colorectal cancer",
abstract = "Background/Aim: We investigated the effect of aspirin on colorectal cancer (CRC) risk among subgroups of women with and without risk factors for CRC. Patients and Methods: Using data from the Women’s Health Initiative, we estimated hazard ratios for CRC in association with aspirin use, with stratifications by cardiovascular disease (CVD) risk status, family history of CRC, and history of colorectal polypectomy. Results: Aspirin was associated with a lower risk of CRC among women with low/normal or high CVD-risk status; no family history of CRC; or a history of colonoscopy with polypectomy. Aspirin was not associated with CRC among women with a family history of CRC or a history of colonoscopy without polypectomy. Conclusion: Aspirin was associated with a lower risk of CRC in women at all levels of CVD-risk, in those with a history of colonoscopy with polypectomy, and in those without a family history of CRC.",
author = "Seaton, {Max E.} and Ulrike Peters and Karen Johnson and Charles Kooperberg and Andrea Bafford and Niha Zubair",
year = "2019",
month = "1",
day = "1",
doi = "10.21873/anticanres.13673",
language = "English (US)",
volume = "39",
pages = "4877--4884",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "9",

}

TY - JOUR

T1 - Effects of colorectal cancer risk factors on the association between aspirin and colorectal cancer

AU - Seaton, Max E.

AU - Peters, Ulrike

AU - Johnson, Karen

AU - Kooperberg, Charles

AU - Bafford, Andrea

AU - Zubair, Niha

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background/Aim: We investigated the effect of aspirin on colorectal cancer (CRC) risk among subgroups of women with and without risk factors for CRC. Patients and Methods: Using data from the Women’s Health Initiative, we estimated hazard ratios for CRC in association with aspirin use, with stratifications by cardiovascular disease (CVD) risk status, family history of CRC, and history of colorectal polypectomy. Results: Aspirin was associated with a lower risk of CRC among women with low/normal or high CVD-risk status; no family history of CRC; or a history of colonoscopy with polypectomy. Aspirin was not associated with CRC among women with a family history of CRC or a history of colonoscopy without polypectomy. Conclusion: Aspirin was associated with a lower risk of CRC in women at all levels of CVD-risk, in those with a history of colonoscopy with polypectomy, and in those without a family history of CRC.

AB - Background/Aim: We investigated the effect of aspirin on colorectal cancer (CRC) risk among subgroups of women with and without risk factors for CRC. Patients and Methods: Using data from the Women’s Health Initiative, we estimated hazard ratios for CRC in association with aspirin use, with stratifications by cardiovascular disease (CVD) risk status, family history of CRC, and history of colorectal polypectomy. Results: Aspirin was associated with a lower risk of CRC among women with low/normal or high CVD-risk status; no family history of CRC; or a history of colonoscopy with polypectomy. Aspirin was not associated with CRC among women with a family history of CRC or a history of colonoscopy without polypectomy. Conclusion: Aspirin was associated with a lower risk of CRC in women at all levels of CVD-risk, in those with a history of colonoscopy with polypectomy, and in those without a family history of CRC.

UR - http://www.scopus.com/inward/record.url?scp=85072164818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072164818&partnerID=8YFLogxK

U2 - 10.21873/anticanres.13673

DO - 10.21873/anticanres.13673

M3 - Article

VL - 39

SP - 4877

EP - 4884

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 9

ER -