Effects of dopamine on pial arteriolar diameter and CSF prostanoid levels in piglets

D. W. Busija, Charles Leffler

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We examined effects of topically applied dopamine on pial arteriolar diameter and CSF prostanoid levels in newborn pigs. Vascular responses were determined using the closed cranial window technique and intravital microscopy, and prostanoids were determined by radioimmunoassay. Topical application of dopamine did not change arteriolar diameter at 10-7-10-5 M, but constricted arterioles at 10-4 (16%) and 10-3 M (30%). Intravenous administration of indomethacin (5 mg/kg) did not alter this constriction. In addition, CSF prostanoid levels did not increase in response to application of dopamine except for a modest increase of prostaglandin E2 at 10-3 M. We conclude that dopamine is a constrictor at high doses of piglet pial arterioles and that this response is not modified by endogenous prostanoids.

Original languageEnglish (US)
Pages (from-to)264-267
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Volume9
Issue number3
DOIs
StatePublished - Jan 1 1989

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Prostaglandins
Dopamine
Arterioles
Dinoprostone
Constriction
Indomethacin
Intravenous Administration
Radioimmunoassay
Blood Vessels
Swine

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Effects of dopamine on pial arteriolar diameter and CSF prostanoid levels in piglets. / Busija, D. W.; Leffler, Charles.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 9, No. 3, 01.01.1989, p. 264-267.

Research output: Contribution to journalArticle

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